Mouse Anti-SASH1 Recombinant Antibody (CBXS-2315) (CBMAB-S5077-CQ)

Name: Mouse Anti-SASH1 Recombinant Antibody (CBXS-2315)
SKU: CBMAB-S5077-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2315

Application

ELISA, WB

Immunogen

SASH1 (NP_056093, 1066aa-1175aa) partial recombinant protein with GST tag

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SAM and SH3 domain containing 1

Introduction

This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients.

Entrez Gene ID

23328

UniProt ID

O94885

Alternative Names

SAM And SH3 Domain Containing 1; Proline-Glutamate Repeat-Containing Protein; SAM And SH3 Domain-Containing Protein 1; DJ323M4.1; KIAA0790; SH3D6A; PEPE1;

Function

Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175).
Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175).
Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659).
Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175).
Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244).

Biological Process

Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:MGI
Biological Process positive regulation of JUN kinase activityManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIMP:MGI
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of protein autoubiquitinationManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of protein K63-linked ubiquitinationManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Cytoplasm

Involvement in disease

Dyschromatosis universalis hereditaria 1 (DUH1):
A form of dyschromatosis universalis, an autosomal dominant pigmentary genodermatosis characterized by a mixture of hyperpigmented and hypopigmented macules distributed randomly over the body, that appear in infancy or early childhood. The trunk and extremities are the dominant sites of abnormal pigmentation. Facial lesions can be seen in 50% of affected individuals, but involvement of palms and soles is unusual. Abnormalities of hair and nails have also been reported. Dyschromatosis universalis hereditaria may be associated with abnormalities of dermal connective tissue, nerve tissue, or other systemic complications.
Cancer, alopecia, pigment dyscrasia, onychodystrophy, and keratoderma (CAPOK):
An autosomal recessive genodermatosis characterized by hypo- and hyperpigmented macular skin lesions, progressive alopecia, palmoplantar keratoderma, dystrophic nails, teeth abnormalities and a predisposition to squamous cell carcinoma.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-SASH1 Recombinant Antibody (X1) (CAT#: CBMAB-S6674-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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