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Mouse Anti-SASH1 Recombinant Antibody (10B7) (CBMAB-A7895-LY)

The product is antibody recognizes SASH1. The antibody 10B7 immunoassay techniques such as: WB, ELISA.
See all SASH1 antibodies
Published Data
Fig. 1 SASH1 protein localises to the periphery of A375 cells.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
10B7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SASH1 (NP_056093, 1066 a.a. ~ 1175 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SAM and SH3 domain containing 1
Entrez Gene ID
23328
UniProt ID
O94885
Alternative Names
KIAA0790; RP3-323M4.1; SH3D6A; dJ323M4; dJ323M4.1
Function
Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175).
Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175).
Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659).
Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175).
Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244).
Biological Process
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:MGI
Biological Process positive regulation of JUN kinase activityManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIMP:MGI
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of protein autoubiquitinationManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of protein K63-linked ubiquitinationManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cytoplasm
Involvement in disease
Dyschromatosis universalis hereditaria 1 (DUH1):
A form of dyschromatosis universalis, an autosomal dominant pigmentary genodermatosis characterized by a mixture of hyperpigmented and hypopigmented macules distributed randomly over the body, that appear in infancy or early childhood. The trunk and extremities are the dominant sites of abnormal pigmentation. Facial lesions can be seen in 50% of affected individuals, but involvement of palms and soles is unusual. Abnormalities of hair and nails have also been reported. Dyschromatosis universalis hereditaria may be associated with abnormalities of dermal connective tissue, nerve tissue, or other systemic complications.
Cancer, alopecia, pigment dyscrasia, onychodystrophy, and keratoderma (CAPOK):
An autosomal recessive genodermatosis characterized by hypo- and hyperpigmented macular skin lesions, progressive alopecia, palmoplantar keratoderma, dystrophic nails, teeth abnormalities and a predisposition to squamous cell carcinoma.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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