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Mouse Anti-SRP54 Recombinant Antibody (CBXS-4632) (CBMAB-S1871-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4632
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-101 from human SRP54 (NP_003127) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signal Recognition Particle 54
Introduction
SRP54 (Signal Recognition Particle 54) is a Protein Coding gene. Diseases associated with SRP54 include Shwachman-Diamond Syndrome. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include GTPase activity.
Entrez Gene ID
6729
UniProt ID
P61011
Alternative Names
Signal Recognition Particle 54; Signal Recognition Particle 54kDa;
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957).
As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957).
Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957).
Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957).
Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957).
SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957).
Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity).
Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977).
Biological Process
Biological Process exocrine pancreas developmentISS:UniProtKB
Biological Process granulocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neutrophil chemotaxisISS:UniProtKB
Biological Process protein targeting to ERManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane1 PublicationIC:MGI
Biological Process SRP-dependent cotranslational protein targeting to membrane, signal sequence recognitionISS:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocationISS:UniProtKB
Cellular Location
Nucleus speckle
Cytoplasm
Endoplasmic reticulum
Involvement in disease
Neutropenia, severe congenital 8, autosomal dominant (SCN8):
A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
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For research use only. Not intended for any clinical use.

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