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Rabbit Anti-SRP54 Recombinant Antibody (CBXS-1260) (CBMAB-S4119-CQ)

This product is a rabbit antibody that recognizes SRP54. The antibody CBXS-1260 can be used for immunoassay techniques such as: WB.
See all SRP54 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1260
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signal Recognition Particle 54
Introduction
SRP54 (Signal Recognition Particle 54) is a Protein Coding gene. Diseases associated with SRP54 include Shwachman-Diamond Syndrome. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include GTPase activity.
Entrez Gene ID
Human6729
Mouse24067
Rat116650
UniProt ID
HumanP61011
MouseP14576
RatQ6AYB5
Alternative Names
Signal Recognition Particle 54; Signal Recognition Particle 54kDa;
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957).
As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957).
Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957).
Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957).
Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957).
SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957).
Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity).
Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977).
Biological Process
Biological Process exocrine pancreas developmentISS:UniProtKB
Biological Process granulocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neutrophil chemotaxisISS:UniProtKB
Biological Process protein targeting to ERManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane1 PublicationIC:MGI
Biological Process SRP-dependent cotranslational protein targeting to membrane, signal sequence recognitionISS:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocationISS:UniProtKB
Cellular Location
Nucleus speckle
Cytoplasm
Endoplasmic reticulum
Involvement in disease
Neutropenia, severe congenital 8, autosomal dominant (SCN8):
A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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