Mouse Anti-STAU2 Recombinant Antibody (CBXS-3281) (CBMAB-S6021-CQ)

Name: Mouse Anti-STAU2 Recombinant Antibody (CBXS-3281)
SKU: CBMAB-S6021-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-3281

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa2-91 from human STAU2 (NP_055208) with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

staufen, RNA binding protein, homolog 2 (Drosophila)

Introduction

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

27067

UniProt ID

Q9NUL3

Alternative Names

39K2; 39K3

Function

RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).

Biological Process

Biological Process anterograde dendritic transport of messenger ribonucleoprotein complexManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to oxidative stressIEA:Ensembl
Biological Process eye morphogenesisIEA:Ensembl
Biological Process germ cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular mRNA localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendritic spine morphogenesisIEA:Ensembl
Biological Process positive regulation of long-term synaptic depressionIEA:Ensembl
Biological Process positive regulation of synapse assemblyIEA:Ensembl
Biological Process protein localization to synapseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton organizationIEA:Ensembl
Biological Process regulation of filopodium assemblyIEA:Ensembl
Biological Process regulation of gene expressionIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Nucleus, nucleolus
Endoplasmic reticulum
Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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