STAU2

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

staufen, RNA binding protein, homolog 2 (Drosophila)

Function

RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).

Biological Process

Biological Process anterograde dendritic transport of messenger ribonucleoprotein complexManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to oxidative stressIEA:Ensembl
Biological Process eye morphogenesisIEA:Ensembl
Biological Process germ cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular mRNA localizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of dendritic spine morphogenesisIEA:Ensembl
Biological Process positive regulation of long-term synaptic depressionIEA:Ensembl
Biological Process positive regulation of synapse assemblyIEA:Ensembl
Biological Process protein localization to synapseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton organizationIEA:Ensembl
Biological Process regulation of filopodium assemblyIEA:Ensembl
Biological Process regulation of gene expressionIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Nucleus, nucleolus
Endoplasmic reticulum
Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity).