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Mouse Anti-TBX19 Recombinant Antibody (CBYJT-2136) (CBMAB-T1239-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBX19 (T-Box 19). The antibody can be used for immunoassay techniques, such as WB.
See all TBX19 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2136
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-238 of human TBX19 (NP_005140) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-238

Target

Full Name
TBX19
Introduction
TBX19 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in TBX19 were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for TBX19 in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure.
Entrez Gene ID
9095
UniProt ID
O60806
Alternative Names
T-Box 19; T-Box Factor, Pituitary; T-Box Protein 19; TBS 19; TPIT; T-Box Transcription Factor TBX19; DJ747L4.1; TBS19
Function
Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.
Biological Process
Biological Process anatomical structure morphogenesisTAS:ProtInc1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process heart morphogenesisIBA:GO_Central1 Publication
Biological Process mesoderm formationIBA:GO_Central1 Publication
Biological Process pituitary gland developmentIEA:Ensembl
Biological Process regulation of cell differentiationIEA:Ensembl
Biological Process regulation of cell population proliferationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
ACTH deficiency, isolated (IAD):
An autosomal recessive disorder that is characterized by adrenal insufficiency symptoms, such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting and low blood pressure (hypotension). The pituitary hormone ACTH is decreased or absent, and other cortisol and other steroid hormone levels in the blood are abnormally low.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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