Mouse Anti-TBX19 Recombinant Antibody (CBYJT-2137) (CBMAB-T1240-YJ)

Name: Mouse Anti-TBX19 Recombinant Antibody (CBYJT-2137)
SKU: CBMAB-T1240-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2137

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-238 of human TBX19 (NP_005140) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-238

More Infomation

Target

Full Name

TBX19

Introduction

TBX19 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in TBX19 were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for TBX19 in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure.

Entrez Gene ID

9095

UniProt ID

O60806

Alternative Names

T-Box 19; T-Box Factor, Pituitary; T-Box Protein 19; TBS 19; TPIT; T-Box Transcription Factor TBX19; DJ747L4.1; TBS19

Function

Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.

Biological Process

Biological Process anatomical structure morphogenesisTAS:ProtInc1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process heart morphogenesisIBA:GO_Central1 Publication
Biological Process mesoderm formationIBA:GO_Central1 Publication
Biological Process pituitary gland developmentIEA:Ensembl
Biological Process regulation of cell differentiationIEA:Ensembl
Biological Process regulation of cell population proliferationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication

Cellular Location

Nucleus

Involvement in disease

ACTH deficiency, isolated (IAD):
An autosomal recessive disorder that is characterized by adrenal insufficiency symptoms, such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting and low blood pressure (hypotension). The pituitary hormone ACTH is decreased or absent, and other cortisol and other steroid hormone levels in the blood are abnormally low.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TBX19 Recombinant Antibody (CBYJT-2136) (CAT#: CBMAB-T1239-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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