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Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683)


See all TNFSF13B antibodies
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Tested Data
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in ELISA
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in ELISA
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in WB
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in WB
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in WB
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in WB
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in WB
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in WB
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in IF
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in IF
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in FC
Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (V2LY-0625-LY683) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4314
Antibody Isotype
IgG1
Application
WB, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human TNFSF13B (AA: 116-278) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:100-1:500
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
10673
Function
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Isoform 3
Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Biological Process
Biological Process B cell costimulation Source:Ensembl
Biological Process B cell differentiation Source:Ensembl
Biological Process B cell homeostasis Source:Ensembl
Biological Process B cell proliferation Source:Ensembl
Biological Process germinal center formation Source:Ensembl
Biological Process positive regulation of B cell proliferation Source:AgBase1 Publication
Biological Process positive regulation of germinal center formation Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell costimulation Source:Ensembl
Biological Process T cell proliferation Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:Ensembl
Cellular Location
Cell membrane
Tumor necrosis factor ligand superfamily member 13b, soluble form
Secreted
Topology
Cytoplasmic: 1-46
Helical: 47-67
Extracellular: 68-285
PTM
The soluble form derives from the membrane form by proteolytic processing.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
N-glycosylated.
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For research use only. Not intended for any clinical use.

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