TNFSF13B
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Full Name
TNFSF13B Gene(Protein Coding) TNF Superfamily Member 13b
Function
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Isoform 3
Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Isoform 3
Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Biological Process
Biological Process B cell costimulation Source:Ensembl
Biological Process B cell differentiation Source:Ensembl
Biological Process B cell homeostasis Source:Ensembl
Biological Process B cell proliferation Source:Ensembl
Biological Process germinal center formation Source:Ensembl
Biological Process positive regulation of B cell proliferation Source:AgBase1 Publication
Biological Process positive regulation of germinal center formation Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell costimulation Source:Ensembl
Biological Process T cell proliferation Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:Ensembl
Biological Process B cell differentiation Source:Ensembl
Biological Process B cell homeostasis Source:Ensembl
Biological Process B cell proliferation Source:Ensembl
Biological Process germinal center formation Source:Ensembl
Biological Process positive regulation of B cell proliferation Source:AgBase1 Publication
Biological Process positive regulation of germinal center formation Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell costimulation Source:Ensembl
Biological Process T cell proliferation Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:Ensembl
Cellular Location
Cell membrane
Tumor necrosis factor ligand superfamily member 13b, soluble form
Secreted
Tumor necrosis factor ligand superfamily member 13b, soluble form
Secreted
Topology
Cytoplasmic: 1-46
Helical: 47-67
Extracellular: 68-285
Helical: 47-67
Extracellular: 68-285
PTM
The soluble form derives from the membrane form by proteolytic processing.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
N-glycosylated.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
N-glycosylated.
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Anti-TNFSF13B antibodies
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CompareTarget: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-2145
Application*: F, IH, WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: CBYY-2144
Application*: F, IH, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1903
Application*: F, P, WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-1899
Application*: E, F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1856
Application*: E, F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1850
Application*: P, C, F
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-1726
Application*: F, MC
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1719
Application*: N
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1716
Application*: F
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-1712
Application*: WB, F, MC
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-1658
Application*: E, FN, IP
Target: TNFSF13B
Host: Mouse
Specificity: Mouse
Clone: CBYY-1231
Application*: IP
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-1230
Application*: WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-1229
Application*: F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1228
Application*: E, I, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1227
Application*: E, F
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: CBYY-1223
Application*: F, IH, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1222
Application*: WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1221
Application*: E
Target: TNFSF13B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1220
Application*: WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1219
Application*: F, WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYY-1218
Application*: F, IH, C, B
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-1217
Application*: WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-1216
Application*: WB, F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-1213
Application*: WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1212
Application*: F, IH
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-1211
Application*: E, F, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1209
Application*: F, IH, FN
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-1208
Application*: E, IP, WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-1207
Application*: F, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1206
Application*: E, IP, WB
Target: TNFSF13B
Host: Mouse
Specificity: Human
Clone: CBYY-1203
Application*: E, WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-1201
Application*: F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1200
Application*: E
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1199
Application*: E, IP
Target: TNFSF13B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1198
Application*: E
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4314
Application*: WB, IC, F
Target: TNFSF13B
Specificity: Human
Target: TNFSF13B
Specificity: Human
Target: TNFSF13B
Specificity: Human
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP220
Application*: ELISA, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G6
Application*: WB, E
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C11
Application*: WB, E
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C11
Application*: WB, E
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-714
Application*: E, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: T7-241
Application*: E, P, FC
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBWJC-4549
Application*: IC, E, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2453
Application*: E
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJT-3945
Application*: WB, IH, F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3944
Application*: E, IH, F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3943
Application*: WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3942
Application*: WB, IC, F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3941
Application*: WB, F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3940
Application*: WB
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3939
Application*: E, FN, IP
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3937
Application*: E, IP
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3936
Application*: E, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3935
Application*: F, WB
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3188
Application*: E
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7H149
Application*: E, F
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D6
Application*: F, C, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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