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TNFSF13B

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Full Name
TNFSF13B Gene(Protein Coding) TNF Superfamily Member 13b
Function
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Isoform 3
Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Biological Process
Biological Process B cell costimulation Source:Ensembl
Biological Process B cell differentiation Source:Ensembl
Biological Process B cell homeostasis Source:Ensembl
Biological Process B cell proliferation Source:Ensembl
Biological Process germinal center formation Source:Ensembl
Biological Process positive regulation of B cell proliferation Source:AgBase1 Publication
Biological Process positive regulation of germinal center formation Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell costimulation Source:Ensembl
Biological Process T cell proliferation Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:Ensembl
Cellular Location
Cell membrane
Tumor necrosis factor ligand superfamily member 13b, soluble form
Secreted
Topology
Cytoplasmic: 1-46
Helical: 47-67
Extracellular: 68-285
PTM
The soluble form derives from the membrane form by proteolytic processing.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
N-glycosylated.

Anti-TNFSF13B antibodies

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Mouse Anti-TNFSF13B Recombinant Antibody (CBWJC-4549) (CBMAB-C5945WJ)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBWJC-4549
Application*: IC, E, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBWJC-2453) (CBMAB-C3517WJ)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2453
Application*: E

Rat Anti-TNFSF13B Recombinant Antibody (CBYJT-3945) (CBMAB-T3352-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJT-3945
Application*: WB, IH, F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYJT-3944) (CBMAB-T3351-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3944
Application*: E, IH, F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYJT-3943) (CBMAB-T3350-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3943
Application*: WB

Rat Anti-TNFSF13B Recombinant Antibody (CBYJT-3942) (CBMAB-T3349-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3942
Application*: WB, IC, F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYJT-3941) (CBMAB-T3348-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3941
Application*: WB, F

Rat Anti-TNFSF13B Recombinant Antibody (CBYJT-3939) (CBMAB-T3346-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3939
Application*: E, FN, IP

Rat Anti-TNFSF13B Recombinant Antibody (CBYJT-3937) (CBMAB-T3344-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3937
Application*: E, IP

Mouse Anti-TNFSF13B Recombinant Antibody (CBYJT-3936) (CBMAB-T3343-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3936
Application*: E, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYJT-3935) (CBMAB-T3342-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3935
Application*: F, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBFYC-3188) (CBMAB-C3265-FY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3188
Application*: E

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-2145) (CBMAB-2494-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-2145
Application*: F, IH, WB

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-2144) (CBMAB-2493-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: CBYY-2144
Application*: F, IH, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1903) (CBMAB-2252-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1903
Application*: F, P, WB

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1726) (CBMAB-2075-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-1726
Application*: F, MC

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1719) (CBMAB-2068-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1719
Application*: N

Mouse Anti-TNFSF13B Recombinant Antibody (CAP220) (CBMAB-AP537LY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP220
Application*: ELISA, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1231) (CBMAB-1235-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Specificity: Mouse
Clone: CBYY-1231
Application*: IP

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1230) (CBMAB-1234-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-1230
Application*: WB

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1229) (CBMAB-1233-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-1229
Application*: F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1228) (CBMAB-1232-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1228
Application*: E, I, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1206) (CBMAB-1210-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1206
Application*: E, IP, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1227) (CBMAB-1231-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1227
Application*: E, F

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1223) (CBMAB-1227-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: CBYY-1223
Application*: F, IH, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYJT-3940) (CBMAB-T3347-YJ)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3940
Application*: WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1209) (CBMAB-1213-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1209
Application*: F, IH, FN

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1222) (CBMAB-1226-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1222
Application*: WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1212) (CBMAB-1216-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1212
Application*: F, IH

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1221) (CBMAB-1225-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1221
Application*: E

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1216) (CBMAB-1220-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-1216
Application*: WB, F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1217) (CBMAB-1221-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-1217
Application*: WB

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1218) (CBMAB-1222-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYY-1218
Application*: F, IH, C, B

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1219) (CBMAB-1223-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1219
Application*: F, WB

Rabbit Anti-TNFSF13B Recombinant Antibody (CBYY-1220) (CBMAB-1224-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1220
Application*: WB

Mouse Anti-TNFSF13B Recombinant Antibody (1D6) (CBMAB-C0506-LY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D6
Application*: F, C, WB

Mouse Anti-TNFSF13B Recombinant Antibody (7H149) (CBMAB-C8776-LY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7H149
Application*: E, F

Mouse Anti-TNFSF13B Recombinant Antibody (T7-241) (CBMAB-C4375-CN)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: T7-241
Application*: E, P, FC

Mouse Anti-TNFSF13B Recombinant Antibody (CBCNC-714) (CBMAB-C4376-CN)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-714
Application*: E, WB

Mouse Anti-TNFSF13B Recombinant Antibody (1C11) (CBMAB-A9357-LY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C11
Application*: WB, E

Mouse Anti-TNFSF13B Recombinant Antibody (2C11) (CBMAB-A9358-LY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C11
Application*: WB, E

Mouse Anti-TNFSF13B Recombinant Antibody (3G6) (CBMAB-A9359-LY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G6
Application*: WB, E

Rabbit Anti-TNFSF13B Recombinant Antibody (CBYY-1198) (CBMAB-1202-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-1198
Application*: E

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1199) (CBMAB-1203-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1199
Application*: E, IP

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1200) (CBMAB-1204-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1200
Application*: E

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1201) (CBMAB-1205-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-1201
Application*: F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1203) (CBMAB-1207-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Specificity: Human
Clone: CBYY-1203
Application*: E, WB

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1207) (CBMAB-1211-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-1207
Application*: F, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1208) (CBMAB-1212-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-1208
Application*: E, IP, WB

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1211) (CBMAB-1215-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-1211
Application*: E, F, WB

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1213) (CBMAB-1217-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-1213
Application*: WB

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1899) (CBMAB-2248-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-1899
Application*: E, F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1856) (CBMAB-2205-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-1856
Application*: E, F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1850) (CBMAB-2199-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1850
Application*: P, C, F

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1716) (CBMAB-2065-YY)

Datasheet SDS
Target: TNFSF13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1716
Application*: F

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1712) (CBMAB-2061-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-1712
Application*: WB, F, MC

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1658) (CBMAB-2007-YY)

Datasheet SDS
Target: TNFSF13B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-1658
Application*: E, FN, IP

TNFSF13B Matched Antibody Pair (1241) (APMAB-1241LY)

Datasheet SDS
Target: TNFSF13B
Specificity: Human

TNFSF13B Matched Antibody Pair (1239) (APMAB-1239LY)

Datasheet SDS
Target: TNFSF13B
Specificity: Human

TNFSF13B Matched Antibody Pair (1240) (APMAB-1240LY)

Datasheet SDS
Target: TNFSF13B
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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