Human Recombinant TNFSF13B protein (V2LY-0526-LY2286)

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Datasheet
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Basic Information

Expressed Host
E. coli
Protein Species
Human
Protein Construction
This product is Human Recombinant TNFSF13B protein consist of Amino Acid: 134-285 and predicts a molecular mass of 17.2 kDa.
Molecule Mass
17.2 kDa
Sequence
Amino Acid: 134-285
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
≥85% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
TNFSF13B Gene(Protein Coding) TNF Superfamily Member 13b
Function
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Isoform 3
Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Biological Process
Biological Process B cell costimulation Source:Ensembl
Biological Process B cell differentiation Source:Ensembl
Biological Process B cell homeostasis Source:Ensembl
Biological Process B cell proliferation Source:Ensembl
Biological Process germinal center formation Source:Ensembl
Biological Process positive regulation of B cell proliferation Source:AgBase1 Publication
Biological Process positive regulation of germinal center formation Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell costimulation Source:Ensembl
Biological Process T cell proliferation Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:Ensembl
Cellular Location
Cell membrane
Tumor necrosis factor ligand superfamily member 13b, soluble form
Secreted
Topology
Cytoplasmic: 1-46
Helical: 47-67
Extracellular: 68-285
PTM
The soluble form derives from the membrane form by proteolytic processing.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
N-glycosylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant TNFSF13B protein, hFc Tag (CAT#: V2LY-0526-LY1205)

Cynomolgus Recombinant TNFSF13B protein, hFc Tag (CAT#: V2LY-0526-LY1390)

Human Recombinant TNFSF13B protein, Trimer , ECD, Biotin Conjugated, AVI & Fc Tag (CAT#: V2LY-0526-LY2287)

Human Recombinant TNFSF13B protein, Trimer , ECD (CAT#: V2LY-0526-LY2288)

Human Recombinant TNFSF13B protein, hFc Tag (CAT#: V2LY-0526-LY2289)

Human Recombinant TNFSF13B protein, Trimer , Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2290)

Human Recombinant TNFSF13B protein, Trimer , His Tag (CAT#: V2LY-0526-LY2291)

TNFSF13B Matched Antibody Pair (1239) (CAT#: APMAB-1239LY)

TNFSF13B Matched Antibody Pair (1240) (CAT#: APMAB-1240LY)

TNFSF13B Matched Antibody Pair (1241) (CAT#: APMAB-1241LY)

Antibody Pairs

TNFSF13B Matched Antibody Pair (1239) (CAT#: APMAB-1239LY)

TNFSF13B Matched Antibody Pair (1240) (CAT#: APMAB-1240LY)

TNFSF13B Matched Antibody Pair (1241) (CAT#: APMAB-1241LY)

Related Products

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1230) (CAT#: CBMAB-1234-YY)

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Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1856) (CAT#: CBMAB-2205-YY)

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1201) (CAT#: CBMAB-1205-YY)

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1726) (CAT#: CBMAB-2075-YY)

Human Recombinant TNFSF13B protein, hFc Tag (CAT#: V2LY-0526-LY2289)

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1216) (CAT#: CBMAB-1220-YY)

Rabbit Anti-TNFSF13B Recombinant Antibody (CBYY-1220) (CAT#: CBMAB-1224-YY)

Cynomolgus Recombinant TNFSF13B protein, hFc Tag (CAT#: V2LY-0526-LY1390)

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1719) (CAT#: CBMAB-2068-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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