Mouse Anti-TNFSF13B Recombinant Antibody (1C11) (CBMAB-A9357-LY)

Name: Mouse Anti-TNFSF13B Recombinant Antibody (1C11)
SKU: CBMAB-A9357-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1C11

Application

WB, ELISA

Immunogen

TNFSF13B (AAH20674, 1 a.a. ~ 285 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TNFSF13B Gene(Protein Coding) TNF Superfamily Member 13b

Introduction

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [provided by RefSeq]

Entrez Gene ID

10673

UniProt ID

Q9Y275

Alternative Names

BAFF; BLYS; CD257; DTL; TALL-1; TALL1; THANK; TNFSF20; ZTNF4

Function

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Isoform 3
Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

Biological Process

Biological Process B cell costimulation Source:Ensembl
Biological Process B cell differentiation Source:Ensembl
Biological Process B cell homeostasis Source:Ensembl
Biological Process B cell proliferation Source:Ensembl
Biological Process germinal center formation Source:Ensembl
Biological Process positive regulation of B cell proliferation Source:AgBase1 Publication
Biological Process positive regulation of germinal center formation Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell costimulation Source:Ensembl
Biological Process T cell proliferation Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:Ensembl

Cellular Location

Cell membrane
Tumor necrosis factor ligand superfamily member 13b, soluble form
Secreted

Topology

Cytoplasmic: 1-46
Helical: 47-67
Extracellular: 68-285

PTM

The soluble form derives from the membrane form by proteolytic processing.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TNFSF13B Matched Antibody Pair (1239) (CAT#: APMAB-1239LY)

TNFSF13B Matched Antibody Pair (1240) (CAT#: APMAB-1240LY)

TNFSF13B Matched Antibody Pair (1241) (CAT#: APMAB-1241LY)

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Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1726) (CAT#: CBMAB-2075-YY)

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1850) (CAT#: CBMAB-2199-YY)

Mouse Anti-TNFSF13B Recombinant Antibody (CBT4314) (CAT#: V2LY-0625-LY683)

Rat Anti-TNFSF13B Recombinant Antibody (CBYY-1658) (CAT#: CBMAB-2007-YY)

Mouse Anti-TNFSF13B Recombinant Antibody (3G6) (CAT#: CBMAB-A9359-LY)

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1208) (CAT#: CBMAB-1212-YY)

Mouse Anti-TNFSF13B Recombinant Antibody (CBYY-1228) (CAT#: CBMAB-1232-YY)

TNFSF13B Matched Antibody Pair (1239) (CAT#: APMAB-1239LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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