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Mouse Anti-ULK2 Recombinant Antibody (3H8) (CBMAB-C4618-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3H8
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa 743-843 from human ULK2 with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4

Target

Full Name
unc-51-like kinase 2 (C. elegans)
Introduction
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
Entrez Gene ID
9706
UniProt ID
Q8IYT8
Alternative Names
Unc-51 Like Autophagy Activating Kinase 2; EC 2.7.11.1; Serine/Threonine-Protein Kinase ULK2; Unc-51 (C. Elegans)-Like Kinase 2; Unc-51-Like Kinase 2 (C. Elegans); Unc-51-Like Kinase 2;
Function
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Biological Process
Biological Process autophagosome assembly Source:GO_Central1 Publication
Biological Process autophagy Source:GO_Central1 Publication
Biological Process autophagy of mitochondrion Source:GO_Central1 Publication
Biological Process axon extension Source:GO_Central1 Publication
Biological Process collateral sprouting Source:Ensembl
Biological Process late nucleophagy Source:GO_Central1 Publication
Biological Process negative regulation of collateral sprouting Source:GO_Central1 Publication
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process piecemeal microautophagy of the nucleus Source:GO_Central1 Publication
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process protein autophosphorylation Source:UniProtKB1 Publication
Biological Process response to starvation Source:UniProtKB
Biological Process reticulophagy Source:GO_Central1 Publication
Biological Process signal transduction Source:InterPro
Cellular Location
Cytoplasmic vesicle membrane
Localizes to pre-autophagosomal membrane.
PTM
Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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