Mouse Anti-ULK2 Recombinant Antibody (1A1) (CBMAB-C4612-CN)

Name: Mouse Anti-ULK2 Recombinant Antibody (1A1)
SKU: CBMAB-C4612-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1A1

Application

ELISA, WB

Immunogen

ULK2 (AAH34988, aa 743-843) partial recombinant protein with GST tag

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

More Infomation

Target

Full Name

unc-51-like kinase 2 (C. elegans)

Introduction

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

Entrez Gene ID

9706

UniProt ID

Q8IYT8

Alternative Names

Unc-51 Like Autophagy Activating Kinase 2; EC 2.7.11.1; Serine/Threonine-Protein Kinase ULK2; Unc-51 (C. Elegans)-Like Kinase 2; Unc-51-Like Kinase 2 (C. Elegans); Unc-51-Like Kinase 2;

Function

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

Biological Process

Biological Process autophagosome assembly Source:GO_Central1 Publication
Biological Process autophagy Source:GO_Central1 Publication
Biological Process autophagy of mitochondrion Source:GO_Central1 Publication
Biological Process axon extension Source:GO_Central1 Publication
Biological Process collateral sprouting Source:Ensembl
Biological Process late nucleophagy Source:GO_Central1 Publication
Biological Process negative regulation of collateral sprouting Source:GO_Central1 Publication
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process piecemeal microautophagy of the nucleus Source:GO_Central1 Publication
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process protein autophosphorylation Source:UniProtKB1 Publication
Biological Process response to starvation Source:UniProtKB
Biological Process reticulophagy Source:GO_Central1 Publication
Biological Process signal transduction Source:InterPro

Cellular Location

Cytoplasmic vesicle membrane
Localizes to pre-autophagosomal membrane.

PTM

Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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