Alzheimer's Disease Research

Alzheimer's Disease (AD) is a progressive neurodegenerative disease that predominantly impacts older adults, making it the most common cause of dementia. It manifests as a constellation of impairments, including memory loss, cognitive decline, language difficulties, visuospatial dysfunction, and emotional disturbances. Genetic factors are believed to contribute to approximately 70% of AD risk, while other potential risk factors include head trauma, depression, and hypertension. AD is marked by distinct pathological features, including amyloid-β (Aβ) plaques aggregation and neurofibrillary tangles (NFTs) formation. These alterations severely disrupt neuronal function and contribute to neuroinflammation and synaptic dysfunction, ultimately leading to neuronal death. Current therapeutic strategies for AD are primarily focused on targeting these pathological features.

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