FDFT1

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq]
Full Name
farnesyl-diphosphate farnesyltransferase 1
Research Area
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
Biological Process
Cholesterol biosynthetic process Source: GO_Central
Farnesyl diphosphate metabolic process Source: GO_Central
Steroid biosynthetic process Source: ProtInc
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
An autosomal recessive disorder characterized by profound developmental delay, brain abnormalities, 2/3 syndactyly of the toes, facial dysmorphisms, low total and LDL-cholesterol, and abnormal urine organic acids.
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Anti-FDFT1 antibodies

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Mouse Anti-FDFT1 Recombinant Antibody (3C2) (V2LY-0925-LY1149)

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Target: FDFT1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C2
Application*: WB, E
Datasheet SDS

Mouse Anti-FDFT1 Recombinant Antibody (CBXF-2941) (V2LY-0925-LY1148)

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Target: FDFT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2941
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-FDFT1 Recombinant Antibody (CBXF-3547) (V2LY-0925-LY1147)

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Target: FDFT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3547
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-FDFT1 Recombinant Antibody (CBXF-3559) (V2LY-0925-LY1146)

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Target: FDFT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-3559
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-FDFT1 Recombinant Antibody (CBXF-1199) (V2LY-0925-LY1145)

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Target: FDFT1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1199
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-FDFT1 Recombinant Antibody (481) (V2LY-0925-LY1144)

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Target: FDFT1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 481
Application*: WB, IH, IF, F
Datasheet SDS

Rabbit Anti-FDFT1 Recombinant Antibody (
10H12) (V2LY-0725-LY1460)

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Target: FDFT1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10H12
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-FDFT1 Recombinant Antibody (3C2) (CBMAB-A2913-LY)

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Target: FDFT1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C2
Application*: WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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