ADCY9

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

Full Name

Adenylate Cyclase 9

Function

Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors.

Biological Process

Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating adrenergic receptor signaling pathway
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cAMP biosynthetic process
Cellular response to glucagon stimulus
G protein-coupled receptor signaling pathway
In utero embryonic development
Negative regulation of inflammatory response to antigenic stimulus
Renal water homeostasis
Signal transduction

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-117 aa
Helical: 118-138 aa
Extracellular: 139-141 aa
Helical: 142-162 aa
Cytoplasmic: 163-171 aa
Helical: 172-192 aa
Extracellular: 193-215 aa
Helical: 216-235 aa
Cytoplasmic: 236-241 aa
Helical: 242-259 aa
Extracellular: 260-280 aa
Helical: 281-301 aa
Cytoplasmic: 302-786 aa
Helical: 787-807 aa
Extracellular: 808-818 aa
Helical: 819-839 aa
Cytoplasmic: 840-867 aa
Helical: 868-888 aa
Extracellular: 889-891 aa
Helical: 892-912 aa
Cytoplasmic: 913-920 aa
Helical: 921-941 aa
Extracellular: 942-975 aa
Helical: 976-996 aa
Cytoplasmic: 997-1353 aa