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Mouse Anti-ADCY9 Recombinant Antibody (V2-179868) (CBMAB-A1246-YC)

Provided herein is a Mouse monoclonal antibody against Human Adenylate Cyclase 9. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all ADCY9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179868
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, ELISA

Basic Information

Immunogen
Adenylate Cyclase 9
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:5,000
IF(ICC)1:50-1:200
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol
Buffer
PBS, pH7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adenylate Cyclase 9
Introduction
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclas
Entrez Gene ID
115
UniProt ID
O60503
Alternative Names
Adenylate Cyclase 9; Adenylate Cyclase Type IX; ATP Pyrophosphate-Lyase 9; Adenylyl Cyclase 9; EC 4.6.1.1; ACIX;
Function
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors.
Biological Process
Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating adrenergic receptor signaling pathway
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cAMP biosynthetic process
Cellular response to glucagon stimulus
G protein-coupled receptor signaling pathway
In utero embryonic development
Negative regulation of inflammatory response to antigenic stimulus
Renal water homeostasis
Signal transduction
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-117 aa
Helical: 118-138 aa
Extracellular: 139-141 aa
Helical: 142-162 aa
Cytoplasmic: 163-171 aa
Helical: 172-192 aa
Extracellular: 193-215 aa
Helical: 216-235 aa
Cytoplasmic: 236-241 aa
Helical: 242-259 aa
Extracellular: 260-280 aa
Helical: 281-301 aa
Cytoplasmic: 302-786 aa
Helical: 787-807 aa
Extracellular: 808-818 aa
Helical: 819-839 aa
Cytoplasmic: 840-867 aa
Helical: 868-888 aa
Extracellular: 889-891 aa
Helical: 892-912 aa
Cytoplasmic: 913-920 aa
Helical: 921-941 aa
Extracellular: 942-975 aa
Helical: 976-996 aa
Cytoplasmic: 997-1353 aa

Rhainds, D., Packard, C. J., Brodeur, M. R., Niesor, E. J., Sacks, F. M., Jukema, J. W., ... & Tardif, J. C. (2021). Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine. Circulation: Genomic and Precision Medicine, 14(2), e003219.

Rautureau, Y., Berlatie, M., Rivas, D., Uy, K., Miquel, G., Higgins, M. E., ... & Tardif, J. C. (2020). Adenylate Cyclase Type 9 Controls Endothelial Cell Function by Regulation of Cyclic Adenosine Monophosphate and Calcium Signaling Pathways. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(Suppl_1), A561-A561.

Rautureau, Y., Berlatie, M., Rivas, D., Uy, K., Miquel, G., Higgins, M. E., ... & Tardif, J. C. (2019). P719 Endothelial expression of adenylate cyclase type 9 (Adcy9) regulates endothelial cell signalling and vasodilation. European Heart Journal, 40(Supplement_1), ehz747-0324.

Yi, H., Wang, K., Jin, J. F., Jin, H., Yang, L., Zou, Y., ... & Liu, X. (2018). Elevated adenylyl cyclase 9 expression is a potential prognostic biomarker for patients with colon cancer. Medical science monitor: international medical journal of experimental and clinical research, 24, 19.

Rautureau, Y., Deschambault, V., Higgins, M. È., Rivas, D., Mecteau, M., Geoffroy, P., ... & Tardif, J. C. (2018). ADCY9 (adenylate cyclase type 9) inactivation protects from atherosclerosis only in the absence of CETP (cholesteryl ester transfer protein). Circulation, 138(16), 1677-1692.

Rautureau, Y., Deschambault, V., Brand, G., Higgins, M. E., Mecteau, M., Uy, K., ... & Tardif, J. C. (2017). Adenylate Cyclase Type 9 Promotes Atherosclerosis in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(suppl_1), A184-A184.

Rautureau, Y., Pouliot, P., Higgins, M. È., Geoffroy, P., Suarez, M. L., Rivas, D., ... & Tardif, J. C. (2017). Adenylate Cyclase Type 9 Regulates Body Weight and Adipose Tissue. Circulation, 136(suppl_1), A15956-A15956.

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For research use only. Not intended for any clinical use.

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