AKR1C1

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
Full Name
Aldo-Keto Reductase Family 1 Member C1
Function
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699).
Biological Process
Bile acid and bile salt transport Source: UniProtKB
Bile acid metabolic process Source: UniProtKB
Cellular response to jasmonic acid stimulus Source: UniProtKB
Cholesterol homeostasis Source: UniProtKB
Daunorubicin metabolic process Source: UniProtKB
Digestion Source: UniProtKB
Doxorubicin metabolic process Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Intestinal cholesterol absorption Source: UniProtKB
Progesterone metabolic process Source: UniProtKB
Prostaglandin metabolic process Source: GO_Central
Response to organophosphorus Source: UniProtKB
Retinal metabolic process Source: UniProtKB
Retinoid metabolic process Source: Reactome
Steroid metabolic process Source: GO_Central
Xenobiotic metabolic process
Cellular Location
Cytosol
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Anti-AKR1C1 antibodies

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Mouse Anti-AKR1C1 Recombinant Antibody (V2-611087) (CBMAB-A0240-LY)

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Target: AKR1C1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-611087
Application*: WB, E
Datasheet SDS

Mouse Anti-AKR1C1 Recombinant Antibody (V2-180476) (CBMAB-A1985-YC)

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Target: AKR1C1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-180476
Application*: WB
Datasheet SDS

Mouse Anti-AKR1C1 Recombinant Antibody (V2-180475) (CBMAB-A1983-YC)

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Target: AKR1C1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180475
Application*: WB, F, E, IC, IF
Datasheet SDS

Mouse Anti-AKR1C1 Recombinant Antibody (V2-31915) (CBMAB-D0005-YC)

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Target: AKR1C1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: V2-31915
Application*: WB, IF, IH, FC
Datasheet SDS

Mouse Anti-AKR1C1 Antibody (V2-2452) (CBMAB-1004CQ)

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Target: AKR1C1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-2452
Application*: P, WB
Datasheet SDS

Mouse Anti-AKR1C1 Recombinant Antibody (CBT3982) (V2LY-0625-LY2027)

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Target: AKR1C1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBT3982
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-AKR1C1 Recombinant Antibody (CBT3929) (V2LY-0625-LY2026)

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Target: AKR1C1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit
Clone: CBT3929
Application*: WB, IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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