ARF6

This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]

ADP Ribosylation Factor 6

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762).
Required for normal completion of mitotic cytokinesis (By similarity).
Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity).
Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216).
Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity).
Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity).
(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Cell adhesion Source: UniProtKB
Cell cycle Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cellular response to nerve growth factor stimulus Source: Ensembl
Cortical actin cytoskeleton organization Source: UniProtKB
Endocytic recycling Source: UniProtKB
Establishment of epithelial cell polarity Source: Ensembl
Hepatocyte apoptotic process Source: Ensembl
Intracellular protein transport Source: GO_Central
Liver development Source: Ensembl
Maintenance of postsynaptic density structure Source: Ensembl
Myeloid cell apoptotic process Source: Ensembl
Negative regulation of dendrite development Source: Ensembl
Negative regulation of protein localization to cell surface Source: Ensembl
Negative regulation of receptor-mediated endocytosis Source: UniProtKB
Nervous system development Source: UniProtKB-KW
Positive regulation of actin filament polymerization Source: UniProtKB
Positive regulation of focal adhesion disassembly Source: ARUK-UCL
Positive regulation of keratinocyte migration Source: ARUK-UCL
Positive regulation of protein localization to plasma membrane Source: BHF-UCL
Positive regulation of protein secretion Source: UniProtKB
Protein localization to cell surface Source: BHF-UCL
Protein localization to endosome Source: UniProtKB
Regulation of dendritic spine development Source: UniProtKB
Regulation of filopodium assembly Source: UniProtKB
Regulation of presynapse assembly Source: Ensembl
Regulation of Rac protein signal transduction Source: UniProtKB
Ruffle assembly Source: UniProtKB
Synaptic vesicle endocytosis Source: Ensembl
Vesicle-mediated transport Source: GO_Central

Endosome membrane; Recycling endosome membrane; Early endosome membrane; Trans-Golgi network membrane; Cell membrane; Filopodium membrane; Cytosol; Ruffle; Cleavage furrow; Midbody ring. Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body (PubMed:23603394). Recruitment to the midbody ring requires both activation by PSD/EFA6A and interaction with KIF23/MKLP1 (By similarity). After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (PubMed:23603394). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles (By similarity). Myristoylation is required for proper localization to membranes (PubMed:7589240).