ASB3

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq]

Full Name

ankyrin repeat and SOCS box-containing 3

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Biological Process

Intracellular signal transduction Source: InterPro
Post-translational protein modification Source: Reactome
Protein localization to T-tubule Source: GO_Central
Protein ubiquitination Source: UniProtKB-UniPathway
Regulation of cardiac muscle contraction Source: GO_Central

Cellular Location

Cytosol; T-tubule