Mouse Anti-ASB3 Recombinant Antibody (3E5) (CBMAB-A3721-YC)

Name: Mouse Anti-ASB3 Recombinant Antibody (3E5)
SKU: CBMAB-A3721-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3E5

Application

ELISA, ICC, IF

Immunogen

ASB3 (AAH06488. 1, 1-518 aa) full-length recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IF(ICC)	10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ankyrin repeat and SOCS box-containing 3

Introduction

ASB3 is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners w

Entrez Gene ID

51130

UniProt ID

Q9Y575

Alternative Names

Ankyrin Repeat And SOCS Box Containing 3; ASB-3; Ankyrin Repeat And SOCS Box-Containing 3; Ankyrin Repeat And SOCS Box Protein 3;

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Biological Process

Intracellular signal transduction Source: InterPro
Post-translational protein modification Source: Reactome
Protein localization to T-tubule Source: GO_Central
Protein ubiquitination Source: UniProtKB-UniPathway
Regulation of cardiac muscle contraction Source: GO_Central

Cellular Location

Cytosol; T-tubule

Zhang, W., Liu, F., Che, Z., Wu, M., Tang, Z., Liu, J., & Yang, D. (2019). ASB3 knockdown promotes mitochondrial apoptosis via activating the interdependent cleavage of Beclin1 and caspase-8 in hepatocellular carcinoma. Science China Life Sciences, 62(12), 1692-1702.

Zylak, A., Hsu, L., Amin, A., Amatya, S., Rajbhandari, S., Feldman, A., ... & Parton, L. A. (2017). The Role of ASB3 Gene Single Nucleotide Polymorphism in the Progression to Bronchopulmonary Dysplasia in Extremely Low Birth Weight Infants.

Du, W. Y., Lu, Z. H., Ye, W., Fu, X., Zhou, Y., Kuang, C. M., ... & Huang, W. L. (2017). The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells. Chinese journal of cancer, 36(1), 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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