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C5

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants.
Full Name
complement C5
Function
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049).
C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Biological Process
Activation of MAPK activity Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Chemotaxis Source: ProtInc
Complement activation Source: Reactome
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: ProtInc
In utero embryonic development Source: Ensembl
Negative regulation of macrophage chemotaxis Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of chemokine production Source: BHF-UCL
Positive regulation of vascular endothelial growth factor production Source: BHF-UCL
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 5 deficiency (C5D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele.

Anti-C5 antibodies

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Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0107
Application*: C, FN, IA, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYA-0106
Application*: C, FN, IA, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYA-0105
Application*: FN, IA, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBFYA-0034
Application*: C, FN, IA, IF, IP, P
Target: C5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-2332
Application*: E, F, IH, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5635
Application*: E, F, C, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Goat, Pig
Clone: HCC5b.1
Application*: E, IH, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2594
Application*: FN, C, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0020
Application*: E, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2368
Application*: WB, E
Target: C5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0659
Application*: ED, N, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-0658
Application*: WB, IF
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0657
Application*: E, FN, C, P, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0656
Application*: E, FN, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0655
Application*: E, WB
Target: C5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0654
Application*: WB, N, EC
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0652
Application*: WB, N, EC
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0651
Application*: ED
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-0650
Application*: E, IH, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0231
Application*: WB, E
Target: C5
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 7L11
Application*: WB, N
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6H13
Application*: N, WB, E
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6A534
Application*: E, C, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6A533
Application*: E, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6A532
Application*: E, N
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Monkey, Pig
Clone: 5F208
Application*: E, IC, C, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F207
Application*: E, C, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 568
Application*: WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 561
Application*: FN
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 557
Application*: WB, FN, I
Target: C5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 442
Application*: E
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 39725
Application*: WB, E, B/N
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 39358
Application*: E, WB, FN
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 2A1
Application*: WB, IC/IF
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2952
Application*: E, FN, C, P, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2942
Application*: R, WB
Target: C5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 241
Application*: E
Target: C5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 215
Application*: P
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10-04-14
Application*: IA, FN, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10-04
Application*: E, FN, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 06
Application*: EC
Target: C5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 295108
Application*: WB, N, EC
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 295003
Application*: WB, N, EC
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig, Horse
Clone: CBYJT-1052
Application*: IA, IC, IF, P, FN
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11F6
Application*: ELISA, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb169
Application*: IHC-F, FuncS, Immuno assays, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBHb168
Application*: IHC-F, FuncS, Immuno assays, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBHb166
Application*: FuncS, Immuno assays
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBHb053
Application*: IHC-F, FuncS, Immuno assays, IF, IP, IHC-P
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLC023-LY
Application*: IA, IC/IF, C, P, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLC024-LY
Application*: IA, FN
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HCC5.1
Application*: IH, E, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8J448
Application*: WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F72
Application*: E, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6A536
Application*: E, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A535
Application*: E, IH, N, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L274
Application*: E, N, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B398
Application*: E, WB
Target: C5
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C3247
Application*: N, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C3228
Application*: N, WB, E
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C3197
Application*: E, IH, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C3196
Application*: E, N
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C3120
Application*: WB, E, B, N
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Goat, Human, Monkey, Pig
Clone: CBYY-C3088
Application*: E, IC, IH, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C3087
Application*: E, IH, WB
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2953
Application*: E, N, WB
Target: C5
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C0819
Application*: WB, N
Target: C5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0818
Application*: E, WB, FN
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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