CA3
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns.
Full Name
CA3
Function
Reversible hydration of carbon dioxide.
Biological Process
Bicarbonate transport Source: Reactome
One-carbon metabolic process Source: GO_Central
Response to bacterium Source: Ensembl
Response to ethanol Source: Ensembl
Response to oxidative stress Source: Ensembl
One-carbon metabolic process Source: GO_Central
Response to bacterium Source: Ensembl
Response to ethanol Source: Ensembl
Response to oxidative stress Source: Ensembl
Cellular Location
Cytoplasm
PTM
S-glutathionylated in hepatocytes under oxidative stress.
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Anti-CA3 antibodies
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CompareTarget: CA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1769
Application*: E
Target: CA3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4A12-1A3
Application*: E, IH, WB
Target: CA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 006
Application*: WB, IP
Target: CA3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 002
Application*: P
Target: CA3
Sensitivity: 1.35 ng/mL
Detection Range: 3-900 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Ca3
Sensitivity: 0.0013 ng/mL
Detection Range: 0.002-0.6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Ca3
Sensitivity: 0.145 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: CA3
Expressed Host: E. coli
Sequence: Amino Acid: 1-260
Tag: His Tag
Target: CA3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Pig
Clone: CBXC-2891
Application*: WB, IF, P, IP
Target: CA3
Host: Mouse
Antibody Isotype: IgG3, ĸ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0254
Application*: E, WB, IF, P, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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