Mouse Anti-CA3 Recombinant Antibody (CBXC-1769) (CBMAB-C3292-CQ)

Name: Mouse Anti-CA3 Recombinant Antibody (CBXC-1769)
SKU: CBMAB-C3292-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-1769

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Recombinant Human Carbonic Anhydrase III / CA3 protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns.

Entrez Gene ID

761

UniProt ID

P07451

Alternative Names

CAIII; Car3

Function

Reversible hydration of carbon dioxide.

Biological Process

Bicarbonate transport Source: Reactome
One-carbon metabolic process Source: GO_Central
Response to bacterium Source: Ensembl
Response to ethanol Source: Ensembl
Response to oxidative stress Source: Ensembl

Cellular Location

Cytoplasm

PTM

S-glutathionylated in hepatocytes under oxidative stress.

More Infomation

References

Liu, D., Wong, C. C., Zhou, Y., Li, C., Chen, H., Ji, F., ... & Yu, J. (2021). Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. Gastroenterology, 160(7), 2467-2482.

NG, B., & Budak, H. (2021). Tip60 Might Be a Candidate For The Acetylation of Hepatic Carbonic Anhydrase I and III in Mice.

BALTACI, N. G., KOCPINAR, E. F., & Budak, H. (2021). Tip60 Might Be a Candidate For The Acetylation of Hepatic Carbonic Anhydrase I and III in Mice.

Aspatwar, A., Hammaren, M., Parikka, M., Parkkila, S., Carta, F., Bozdag, M., ... & Supuran, C. T. (2020). In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono-and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos. Journal of enzyme inhibition and medicinal chemistry, 35(1), 65-71.

Barhwal, K. K., Biswal, S., Nag, T. C., Chaurasia, O. P., & Hota, S. K. (2020). Class switching of carbonic anhydrase isoforms mediates remyelination in CA3 hippocampal neurons during chronic hypoxia. Free Radical Biology and Medicine, 161, 102-114.

Roy, P., Ireland, M., Roy, S., Craft, J., & Bartholomew, C. (2018). Carbonic Anhydrase III S-Glutathionylation Is Necessary for Anti-Oxidant Activity. Yangtze Medicine, 2(04), 244.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

CA3 Matched Antibody Pair (164) (CAT#: APMAB-164LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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