CAPZA2

CAPZA2 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA1.

Full Name

Capping Actin Protein Of Muscle Z-Line Alpha Subunit 2

Function

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Biological Process

Actin cytoskeleton organization Source: GO_Central
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Barbed-end actin filament capping Source: GO_Central
Blood coagulation Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Innate immune response Source: Reactome
Protein-containing complex assembly Source: ProtInc

Cellular Location

Actin cytoskeleton; Cortical cytoskeleton; F-actin capping protein complex; Cytosol; Extracellular exosome; Extracellular region; Brush border; Membrane