DGKQ

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

Full Name

Diacylglycerol Kinase Theta

Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9099683, PubMed:11309392, PubMed:22627129).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701).

Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281).

Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity).

Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701).

Biological Process

cAMP-mediated signaling Source: UniProtKB
Diacylglycerol metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: UniProtKB
Intracellular signal transduction Source: GO_Central
Lipid phosphorylation Source: UniProtKB
Negative regulation of gene expression Source: ParkinsonsUK-UCL
Negative regulation of peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Phosphatidic acid biosynthetic process Source: UniProtKB
Platelet activation Source: Reactome
Positive regulation of gene expression Source: ParkinsonsUK-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: ParkinsonsUK-UCL
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Protein kinase C signaling Source: UniProtKB
Regulation of cholesterol metabolic process Source: ParkinsonsUK-UCL
Regulation of cortisol biosynthetic process Source: ParkinsonsUK-UCL
Regulation of gluconeogenesis Source: ParkinsonsUK-UCL
Regulation of G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
Regulation of progesterone biosynthetic process Source: ParkinsonsUK-UCL
Regulation of synaptic vesicle endocytosis Source: Ensembl
Regulation of TORC1 signaling Source: ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase II Source: UniProtKB
Response to ATP Source: UniProtKB
Response to cAMP Source: ParkinsonsUK-UCL
Thrombin-activated receptor signaling pathway Source: UniProtKB

Cellular Location

Nucleus; Nucleus speckle; Nucleus matrix; Cell membrane; Cytoplasm; Cytosol; Cytoskeleton; Synapse. Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189). Translocates to the nucleus in response to thrombin stimulation (Probable). Association with the nuclear matrix is regulated by nerve growth factor (By similarity).

PTM

Phosphorylated by PRKCE and PRKCH in vitro.