DOK1

DOK1 is part of a signal transduction pathway downstream of receptor tyrosine kinases. The protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes.

Full Name

Docking Protein 1

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Macrophage colony-stimulating factor signaling pathway Source: Ensembl
Ras protein signal transduction Source: Ensembl
Signal transduction Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Cellular Location

Isoform 1: Nucleus; Cytoplasm
Isoform 3: Perinuclear region

PTM

Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.

Anti-DOK1 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-dok1 Recombinant Antibody (P0282) (CBMAB-P0282-YC)

Datasheet

SDS

Target: DOK1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: P0282

Application*: WB, IP, IF, P

Rabbit Anti-DOK1 Recombinant Antibody (EG986) (V2LY-0425-LY784)

Datasheet

SDS

Target: DOK1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG986

Application*: IF, WB

Rabbit Anti-DOK1 Recombinant Antibody (EG985) (V2LY-0425-LY783)

Datasheet

SDS

Target: DOK1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG985

Application*: WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)