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DSG2

This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]
Full Name
Desmoglein 2
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Biological Process
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Desmosome organization Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Purkinje myocyte development Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Cardiomyopathy, dilated 1BB (CMD1BB):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Topology
Extracellular: 50-609
Helical: 610-634
Cytoplasmic: 635-1118

Anti-DSG2 antibodies

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb196
Application*: IHC-F, IF, IP, WB
Target: DSG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1000
Application*: WB: 1:500~1:1000 ELISA: 1:40000
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B2714
Application*: C, IP, WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D37
Application*: WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D8
Application*: IC, IF, IP, WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H9
Application*: WB, IC, IF
Target: DSG2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CSTEM28
Application*: F, IC
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Mouse, Rat
Clone: DG3-10
Application*: IF, C, P, WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G129
Application*: E, IC, IH, WB
Target: DSG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCD-421
Application*: WB, IP, F
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0125
Application*: C, IF, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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