DSG2

This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]
Full Name
Desmoglein 2
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Biological Process
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Desmosome organization Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Purkinje myocyte development Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Cardiomyopathy, dilated 1BB (CMD1BB):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Topology
Extracellular: 50-609
Helical: 610-634
Cytoplasmic: 635-1118
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Anti-DSG2 antibodies

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Mouse Anti-DSG2 Recombinant Antibody (29) (CBMAB-D1772-YC)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 29
Application*: WB, IP
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (28) (CBMAB-D1771-YC)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 28
Application*: WB, IP, IF, E
Datasheet SDS

Recombinant Mouse Anti-DSG2 Antibody (CBHb196) (CBMAB-Hb432-LY)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb196
Application*: IHC-F, IF, IP, WB
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (CBFYA-0125) (CBMAB-X0182-FY)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0125
Application*: C, IF, IP, WB
Datasheet SDS

Rabbit Anti-DSG2 Recombinant Antibody (CBYCD-421) (CBMAB-D1776-YC)

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Target: DSG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCD-421
Application*: WB, IP, F
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (G129) (CBMAB-D1773-YC)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G129
Application*: E, IC, IH, WB
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (7H9) (CBMAB-D1770-YC)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H9
Application*: WB, IC, IF
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (6D8) (CBMAB-D1769-YC)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D8
Application*: IC, IF, IP, WB
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (5D37) (CBMAB-D1768-YC)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D37
Application*: WB
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (10B2714) (CBMAB-D1763-YC)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B2714
Application*: C, IP, WB
Datasheet SDS

Human Anti-DSG2 Recombinant Antibody (
22H6) (V2LY-0725-LY1322)

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Target: DSG2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 22H6
Application*: E
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (CBHb196) (V2LY-0425-LY989)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb196
Application*: IH, WB
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (CBFYA-0125) (V2LY-0425-LY988)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYA-0125
Application*: WB, IP, IF, P
Datasheet SDS

Rabbit Anti-DSG2 Recombinant Antibody (CBYCD-421) (V2LY-0425-LY987)

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Target: DSG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCD-421
Application*: WB, P, F
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (G129) (V2LY-0425-LY986)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: G129
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (D1770) (V2LY-0425-LY983)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D1770
Application*: WB, IF
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (D1769) (V2LY-0425-LY982)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: D1769
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (5D37) (V2LY-0425-LY981)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5D37
Application*: WB, F, IF
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (10B2714) (V2LY-0425-LY980)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 10B2714
Application*: F, IF
Datasheet SDS

Human Anti-DSG2 Recombinant Antibody (XB0369) (V2LY-0425-LY979)

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Target: DSG2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: XB0369
Application*: E
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (D1762) (V2LY-0425-LY978)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D1762
Application*: P
Datasheet SDS

Mouse Anti-DSG2 Recombinant Antibody (D1761) (V2LY-0425-LY977)

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Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: D1761
Application*: WB, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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