DSG2
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]
Full Name
Desmoglein 2
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Biological Process
Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Desmosome organization Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Purkinje myocyte development Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Desmosome organization Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Purkinje myocyte development Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Cardiomyopathy, dilated 1BB (CMD1BB):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Cardiomyopathy, dilated 1BB (CMD1BB):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Topology
Extracellular: 50-609
Helical: 610-634
Cytoplasmic: 635-1118
Helical: 610-634
Cytoplasmic: 635-1118
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Anti-DSG2 antibodies
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CompareTarget: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 29
Application*: WB, IP
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 28
Application*: WB, IP, IF, E
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb196
Application*: IHC-F, IF, IP, WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0125
Application*: C, IF, IP, WB
Target: DSG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCD-421
Application*: WB, IP, F
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G129
Application*: E, IC, IH, WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H9
Application*: WB, IC, IF
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D8
Application*: IC, IF, IP, WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D37
Application*: WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B2714
Application*: C, IP, WB
Target: Dsg2
Sensitivity: 0.023 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: DSG2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 50-609
Tag: His Tag
Target: DSG2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 22H6
Application*: E
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb196
Application*: IH, WB
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYA-0125
Application*: WB, IP, IF, P
Target: DSG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCD-421
Application*: WB, P, F
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: G129
Application*: WB, IP, IF, E
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D1770
Application*: WB, IF
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: D1769
Application*: WB, IP, IF
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5D37
Application*: WB, F, IF
Target: DSG2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 10B2714
Application*: F, IF
Target: DSG2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: XB0369
Application*: E
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D1762
Application*: P
Target: DSG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: D1761
Application*: WB, P
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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