Cynomolgus Recombinant DSG2 protein, ECD, His Tag (V2LY-0526-LY1479)

Name: Cynomolgus Recombinant DSG2 protein, ECD, His Tag
SKU: V2LY-0526-LY1479
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Cynomolgus

Tag

His Tag

Protein Construction

This product is Cynomolgus Recombinant DSG2 protein, ECD, His Tag consist of Amino Acid: 50-609 and predicts a molecular mass of 64.13 kDa.

Molecule Mass

64.13 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 50-609

Species

Cynomolgus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥85% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Desmoglein 2

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Biological Process

Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Desmosome organization Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Purkinje myocyte development Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL

Cellular Location

Cell membrane; Desmosome

Involvement in disease

Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Cardiomyopathy, dilated 1BB (CMD1BB):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Topology

Extracellular: 50-609
Helical: 610-634
Cytoplasmic: 635-1118

Brodehl, A., Meshkov, A., Myasnikov, R., Kiseleva, A., Kulikova, O., Klauke, B., ... & Milting, H. (2021). Hemi-and homozygous loss-of-function mutations in dsg2 (Desmoglein-2) cause recessive arrhythmogenic cardiomyopathy with an early onset. International journal of molecular sciences, 22(7), 3786.

Sun, R., Ma, C., Wang, W., & Yang, S. (2020). Upregulation of desmoglein 2 and its clinical value in lung adenocarcinoma: a comprehensive analysis by multiple bioinformatics methods. PeerJ, 8, e8420.

Kim, J., Beidler, P., Wang, H., Li, C., Quassab, A., Coles, C., ... & Lieber, A. (2020). Desmoglein-2 as a prognostic and biomarker in ovarian cancer. Cancer Biology & Therapy, 21(12), 1154-1162.

Debus, J. D., Milting, H., Brodehl, A., Kassner, A., Anselmetti, D., Gummert, J., & Gaertner-Rommel, A. (2019). In vitro analysis of arrhythmogenic cardiomyopathy associated desmoglein-2 (DSG2) mutations reveals diverse glycosylation patterns. Journal of molecular and cellular cardiology, 129, 303-313.

Hermida, A., Fressart, V., Hidden‐Lucet, F., Donal, E., Probst, V., Deharo, J. C., ... & Gandjbakhch, E. (2019). High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia. European journal of heart failure, 21(6), 792-800.

Han, C. P., Yu, Y. H., Wang, A. G., Tian, Y., Zhang, H. T., Zheng, Z. M., & Liu, Y. S. (2018). Desmoglein-2 overexpression predicts poor prognosis in hepatocellular carcinoma patients. Eur Rev Med Pharmacol Sci, 22(17), 5481-5489.

Gross, A., Pack, L. A., Schacht, G. M., Kant, S., Ungewiss, H., Meir, M., ... & Strnad, P. (2018). Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal immunology, 11(6), 1630-1639.

Hütz, K., Zeiler, J., Sachs, L., Ormanns, S., & Spindler, V. (2017). Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Molecular Carcinogenesis, 56(8), 1884-1895.

Ungewiß, H., Vielmuth, F., Suzuki, S. T., Maiser, A., Harz, H., Leonhardt, H., ... & Waschke, J. (2017). Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase. Scientific reports, 7(1), 1-10.

Overmiller, A. M., Pierluissi, J. A., Wermuth, P. J., Sauma, S., Martinez‐Outschoorn, U., Tuluc, M., ... & Mahoney, M. G. (2017). Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes. The FASEB Journal, 31(8), 3412-3424.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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