Mouse Anti-DSG2 Recombinant Antibody (D1770) (V2LY-0425-LY983)

Name: Mouse Anti-DSG2 Recombinant Antibody (D1770)
SKU: V2LY-0425-LY983
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-DSG2 Recombinant Antibody (D1770) (V2LY-0425-LY983-1) in IF

Representative BM trephine biopsy from a MM patient stained by immunofluorescence for DSG2 and CD138 and mounted with DAPI as indicated. Scale bar=20μm. ...View More

Ebert, L. M., Vandyke, K., Johan, M. Z., DeNichilo, M., Tan, L. Y., Myo Min, K. K., ... & Bonder, C. S. (2022). Desmoglein-2 expression is an independent predictor of poor prognosis patients with multiple myeloma. Molecular oncology, 16(6), 1221-1240.

Mouse Anti-DSG2 Recombinant Antibody (D1770) (V2LY-0425-LY983-2) in IHC

BM trephine biopsies from three MM patients were stained for DSG2 by immunohistochemistry; a representative example shows the isotype control (iso ctl) and DSG2-stained section with a DSG2-expressing blood vessel (black arrow) and MM PC (red arrows). ...View More

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

D1770

Application

WB, IF

Immunogen

Recombinant human Desmoglein-2 (Ala50-Gly608).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	2 µg/ml
IF(ICC)	5-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Trehalose & PBS

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Desmoglein 2

Entrez Gene ID

1829

UniProt ID

Q14126

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Biological Process

Bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
Cell adhesion Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Desmosome organization Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Purkinje myocyte development Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL

Cellular Location

Cell membrane; Desmosome

Involvement in disease

Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10):
A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Cardiomyopathy, dilated 1BB (CMD1BB):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Topology

Extracellular: 50-609
Helical: 610-634
Cytoplasmic: 635-1118

Brodehl, A., Meshkov, A., Myasnikov, R., Kiseleva, A., Kulikova, O., Klauke, B., ... & Milting, H. (2021). Hemi-and homozygous loss-of-function mutations in dsg2 (Desmoglein-2) cause recessive arrhythmogenic cardiomyopathy with an early onset. International journal of molecular sciences, 22(7), 3786.

Sun, R., Ma, C., Wang, W., & Yang, S. (2020). Upregulation of desmoglein 2 and its clinical value in lung adenocarcinoma: a comprehensive analysis by multiple bioinformatics methods. PeerJ, 8, e8420.

Kim, J., Beidler, P., Wang, H., Li, C., Quassab, A., Coles, C., ... & Lieber, A. (2020). Desmoglein-2 as a prognostic and biomarker in ovarian cancer. Cancer Biology & Therapy, 21(12), 1154-1162.

Debus, J. D., Milting, H., Brodehl, A., Kassner, A., Anselmetti, D., Gummert, J., & Gaertner-Rommel, A. (2019). In vitro analysis of arrhythmogenic cardiomyopathy associated desmoglein-2 (DSG2) mutations reveals diverse glycosylation patterns. Journal of molecular and cellular cardiology, 129, 303-313.

Hermida, A., Fressart, V., Hidden‐Lucet, F., Donal, E., Probst, V., Deharo, J. C., ... & Gandjbakhch, E. (2019). High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia. European journal of heart failure, 21(6), 792-800.

Han, C. P., Yu, Y. H., Wang, A. G., Tian, Y., Zhang, H. T., Zheng, Z. M., & Liu, Y. S. (2018). Desmoglein-2 overexpression predicts poor prognosis in hepatocellular carcinoma patients. Eur Rev Med Pharmacol Sci, 22(17), 5481-5489.

Gross, A., Pack, L. A., Schacht, G. M., Kant, S., Ungewiss, H., Meir, M., ... & Strnad, P. (2018). Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal immunology, 11(6), 1630-1639.

Hütz, K., Zeiler, J., Sachs, L., Ormanns, S., & Spindler, V. (2017). Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells. Molecular Carcinogenesis, 56(8), 1884-1895.

Ungewiß, H., Vielmuth, F., Suzuki, S. T., Maiser, A., Harz, H., Leonhardt, H., ... & Waschke, J. (2017). Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase. Scientific reports, 7(1), 1-10.

Overmiller, A. M., Pierluissi, J. A., Wermuth, P. J., Sauma, S., Martinez‐Outschoorn, U., Tuluc, M., ... & Mahoney, M. G. (2017). Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes. The FASEB Journal, 31(8), 3412-3424.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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