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DTNA

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Full Name
Dystrobrevin Alpha
Research Area
May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Biological Process
Chemical synaptic transmission Source: ProtInc
Neuromuscular synaptic transmission Source: ProtInc
Signal transduction Source: ProtInc
Striated muscle contraction Source: ProtInc
Synaptic signaling Source: GO_Central
Cellular Location
Cell membrane; Cytoplasm; Synapse. In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.
Involvement in disease
Left ventricular non-compaction 1 (LVNC1):
A form of left ventricular non-compaction, a cardiomyopathy due to myocardial morphogenesis arrest and characterized by a hypertrophic left ventricle, a severely thickened 2-layered myocardium, numerous prominent trabeculations, deep intertrabecular recesses, and poor systolic function. Clinical manifestations are variable. Some affected individuals experience no symptoms at all, others develop heart failure. In some cases, left ventricular non-compaction is associated with other congenital heart anomalies. LVNC1 is an autosomal dominant condition.
PTM
Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus.

Anti-DTNA antibodies

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Target: DTNA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit
Clone: 23/Dystrobrevin
Application*: WB, IH
Target: DTNA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1G1
Application*: WB, IF
Target: DTNA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B11
Application*: F
Target: DTNA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-33724
Application*: F
Target: DTNA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EPR14112
Application*: P, IC, IF, F, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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