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E2F4

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Full Name
E2F4
Research Area
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
Biological Process
Animal organ morphogenesis Source: Ensembl
Blood circulation Source: Ensembl
Cell volume homeostasis Source: Ensembl
Centriole assembly Source: UniProtKB
Epithelial cell development Source: Ensembl
Motile cilium assembly Source: UniProtKB
Multi-ciliated epithelial cell differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of cell population proliferation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Ensembl
Cellular Location
Nucleus
PTM
Differentially phosphorylated in vivo.
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Anti-E2F4 antibodies

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Rabbit Anti-E2F4 Recombinant Antibody (CP0525) (V2LY-0425-LY1246)

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Target: E2F4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CP0525
Application*: IP, WB
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0375) (V2LY-0425-LY1245)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0375
Application*: WB, E
Datasheet SDS

Mouse Anti-E2F4 Monoclonal Antibody (CBFYE-0373) (V2LY-0425-LY1244)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0373
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-E2F4 Monoclonal Antibody (CBFYE-0371) (V2LY-0425-LY1243)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0371
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0007) (V2LY-0425-LY1242)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0007
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0006) (V2LY-0425-LY1241)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0006
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0005) (V2LY-0425-LY1240)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0005
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (E0675) (V2LY-0425-LY1239)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: E0675
Application*: IP, WB
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (0322) (V2LY-0425-LY1238)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 0322
Application*: IP, WB
Datasheet SDS

Rabbit Anti-E2F4 Recombinant Antibody (E3G2G) (CBMAB-CP0525-LY)

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Target: E2F4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: E3G2G
Application*: WB, IP, CI
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0375) (CBMAB-E0677-FY)

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Target: E2F4
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYE-0375
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0373) (CBMAB-E0674-FY)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0373
Application*: GS, IP, WB
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0371) (CBMAB-E0672-FY)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYE-0371
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0007) (CBMAB-E0015-FY)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0007
Application*: IH, WB
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (CBFYE-0006) (CBMAB-E0014-FY)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0006
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-E2F4 (AA 211-301) Recombinant Antibody (CBFYE-0005) (CBMAB-E0012-FY)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0005
Application*: E, WB
Datasheet SDS

Mouse Anti-E2F4 Recombinant Antibody (TFE42) (CBMAB-E0675-FY)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: TFE42
Application*: IC, IP, WB
Datasheet SDS

Mouse Anti-E2F4 Antibody (2H10) (CBMAB-0322-YC)

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Target: E2F4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H10
Application*: E, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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