Sign in or Register

Keywords Search | Target Search

FCN1

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

Full Name

Ficolin 1

Research Area

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097).

Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Biological Process

Cell surface pattern recognition receptor signaling pathway Source: UniProtKB
Complement activation, lectin pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB

Cellular Location

Secreted; Cell membrane. Found on the monocyte and granulocyte surface (PubMed:20400674).

Anti-FCN1 antibodies

Mouse Anti-FCN1 Recombinant Antibody (CBYCL-121) (CBMAB-L0022-YC)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYCL-121

Application*: E, WB

Mouse Anti-FCN1 Recombinant Antibody (CBFYA-0165) (CBMAB-X0238-FY)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYA-0165

Application*: F, IA, WB

Mouse Anti-FCN1 Recombinant Antibody (NA) (CBMAB-AO454LY)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: NA

Application*: ELISA

Recombinant Mouse Anti-Fcn1 Antibody (CBHb254) (CBMAB-Hb482-LY)

SDS

Target: Fcn1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb254

Application*: FC, Immuno assays, WB

Mouse Anti-FCN1 Recombinant Antibody (2B7) (CBMAB-A2911-LY)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B7

Application*: WB, E

Mouse Anti-FCN1 (AA 95-314) Recombinant Antibody (CBFYM-1089) (CBMAB-M1244-FY)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-1089

Application*: E, IH

Mouse Anti-FCN1 Recombinant Antibody (CBXF-2933) (CBMAB-F3640-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXF-2933

Application*: E, WB

Mouse Anti-FCN1 Recombinant Antibody (CBXF-2932) (CBMAB-F3639-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-2932

Application*: E, F, WB

Mouse Anti-FCN1 Recombinant Antibody (CBXF-2930) (CBMAB-F3637-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-2930

Application*: E

Mouse Anti-FCN1 Recombinant Antibody (CBXF-1860) (CBMAB-F3395-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1860

Application*: P

Rabbit Anti-FCN1 Recombinant Antibody (CBXF-1859) (CBMAB-F3394-CQ)

SDS

Target: FCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1859

Application*: P

Mouse Anti-FCN1 Recombinant Antibody (CBXF-1858) (CBMAB-F3393-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1858

Application*: ED

Mouse Anti-FCN1 Recombinant Antibody (CBXF-1857) (CBMAB-F3392-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1857

Application*: EC

Rabbit Anti-FCN1 Recombinant Antibody (CBXF-1856) (CBMAB-F3391-CQ)

SDS

Target: FCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1856

Application*: E

Mouse Anti-FCN1 Recombinant Antibody (CBXF-0475) (CBMAB-F2292-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0475

Application*: E, WB

Mouse Anti-FCN1 (AA 95-314) Recombinant Antibody (CBXF-0474) (CBMAB-F2291-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0474

Application*: E

Mouse Anti-FCN1 Recombinant Antibody (CBXF-0476) (CBMAB-F1433-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-0476

Application*: WB, IC, P, C, E

Rabbit Anti-FCN1 Recombinant Antibody (CBXF-1373) (CBMAB-F1208-CQ)

SDS

Target: FCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1373

Application*: E

Mouse Anti-FCN1 Recombinant Antibody (1E2B1) (CBMAB-F1207-CQ)

SDS

Target: FCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1E2B1

Application*: E

Rabbit Anti-FCN1 Recombinant Antibody (CBXF-1956) (CBMAB-F0730-CQ)

SDS

Target: FCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1956

Application*: P

FCN1 Matched Antibody Pair (421) (APMAB-421LY)

SDS

Target: FCN1

Specificity: Human

FCN1 Matched Antibody Pair (420) (APMAB-420LY)

SDS

Target: FCN1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Go to
Compare