FCN1
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
Full Name
Ficolin 1
Research Area
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097).
Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
Biological Process
Cell surface pattern recognition receptor signaling pathway Source: UniProtKB
Complement activation, lectin pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB
Complement activation, lectin pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB
Cellular Location
Secreted; Cell membrane. Found on the monocyte and granulocyte surface (PubMed:20400674).
View more
Anti-FCN1 antibodies
+ Filters
Loading...
CompareTarget: FCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0474
Application*: E
Target: FCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-121
Application*: E, WB, IP
Target: FCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-326
Tag: His Tag
Target: FCN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-326
Tag: hFc Tag
Target: FCN1
Specificity: Human
Target: FCN1
Specificity: Human
Target: FCN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0475
Application*: E, WB
Target: FCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0476
Application*: P
Target: FCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1373
Application*: E
Target: FCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1956
Application*: P
More Infomation
Hot products 
-
Mouse Anti-GLP1R Recombinant Antibody (4F3) (CBMAB-G0521-LY)
-
Mouse Anti-FOXL1 Recombinant Antibody (CBXF-0845) (CBMAB-F0462-CQ)
-
Mouse Anti-DLG1 Monolconal Antibody (4F3) (CBMAB-0225-CN)
-
Mouse Anti-COL1A2 Recombinant Antibody (CF108) (V2LY-1206-LY626)
-
Mouse Anti-DDC Recombinant Antibody (8E8) (CBMAB-0992-YC)
-
Mouse Anti-ALB Recombinant Antibody (V2-363290) (CBMAB-S0173-CQ)
-
Mouse Anti-ARID3A Antibody (A4) (CBMAB-0128-YC)
-
Mouse Anti-AMACR Recombinant Antibody (CB34A) (CBMAB-CA034LY)
-
Mouse Anti-FOXA3 Recombinant Antibody (2A9) (CBMAB-0377-YC)
-
Mouse Anti-dsDNA Recombinant Antibody (22) (CBMAB-AP1954LY)
-
Mouse Anti-ARG1 Recombinant Antibody (CBYCL-103) (CBMAB-L0004-YC)
-
Mouse Anti-CD1C Recombinant Antibody (L161) (CBMAB-C2173-CQ)
-
Mouse Anti-BACE1 Recombinant Antibody (CBLNB-121) (CBMAB-1180-CN)
-
Mouse Anti-C5b-9 Recombinant Antibody (aE11) (CBMAB-AO138LY)
-
Rabbit Anti-ENO2 Recombinant Antibody (BA0013) (CBMAB-0272CQ)
-
Mouse Anti-AAV-5 Recombinant Antibody (V2-503417) (CBMAB-V208-1369-FY)
-
Mouse Anti-FLI1 Recombinant Antibody (CBXF-0733) (CBMAB-F0435-CQ)
-
Mouse Anti-GFP Recombinant Antibody (28) (CBMAB-G3038-LY)
-
Rabbit Anti-CBL Recombinant Antibody (D4E10) (CBMAB-CP0149-LY)
-
Mouse Anti-BLNK Recombinant Antibody (CBYY-0623) (CBMAB-0626-YY)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry