FCN1

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
Full Name
Ficolin 1
Research Area
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097).

Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
Biological Process
Cell surface pattern recognition receptor signaling pathway Source: UniProtKB
Complement activation, lectin pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB
Cellular Location
Secreted; Cell membrane. Found on the monocyte and granulocyte surface (PubMed:20400674).
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Anti-FCN1 antibodies

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Mouse Anti-FCN1 Recombinant Antibody (CBXF-0474) (CBMAB-F2291-CQ)

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Target: FCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0474
Application*: E
Datasheet SDS

Mouse Anti-FCN1 Recombinant Antibody (CBYCL-121) (CBMAB-L0022-YC)

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Target: FCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-121
Application*: E, WB, IP
Datasheet SDS

FCN1 Matched Antibody Pair (421) (APMAB-421LY)

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Target: FCN1
Specificity: Human
Datasheet SDS

FCN1 Matched Antibody Pair (420) (APMAB-420LY)

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Target: FCN1
Specificity: Human
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Mouse Anti-FCN1 Recombinant Antibody (CBXF-0475) (CBMAB-F2292-CQ)

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Target: FCN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0475
Application*: E, WB
Datasheet SDS

Mouse Anti-FCN1 Recombinant Antibody (CBXF-0476) (CBMAB-F1433-CQ)

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Target: FCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0476
Application*: P
Datasheet SDS

Rabbit Anti-FCN1 Recombinant Antibody (CBXF-1373) (CBMAB-F1208-CQ)

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Target: FCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1373
Application*: E
Datasheet SDS

Rabbit Anti-FCN1 Recombinant Antibody (CBXF-1956) (CBMAB-F0730-CQ)

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Target: FCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1956
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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