Human Recombinant FCN1 protein, His Tag (V2LY-0526-LY4144)

Name: Human Recombinant FCN1 protein, His Tag
SKU: V2LY-0526-LY4144
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant FCN1 protein, His Tag consist of Amino Acid: 1-326 and predicts a molecular mass of 33.6 kDa.

Molecule Mass

33.6 kDa

Sequence

Amino Acid: 1-326

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Ficolin 1

Research Area

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097).

Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Biological Process

Cell surface pattern recognition receptor signaling pathway Source: UniProtKB
Complement activation, lectin pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB

Cellular Location

Secreted; Cell membrane. Found on the monocyte and granulocyte surface (PubMed:20400674).

Xue, D., Tabib, T., Morse, C., Yang, Y., Domsic, R. T., Khanna, D., & Lafyatis, R. (2022). Expansion of Fcγ Receptor IIIa–Positive Macrophages, Ficolin 1–Positive Monocyte‐Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis. Arthritis & Rheumatology, 74(2), 329-341.

Luo, J., Wang, T., Wang, X., Shi, Y., Zhang, Y., Tian, J., & Gong, Y. (2022). Ficolin-3 may act as a tumour suppressor by recognising O-GlcNAcylation site in hepatocellular carcinoma. Medical Hypotheses, 166, 110899.

Li, Y., You, E. Q., Lin, W. H., Liu, X. N., Shen, D. P., Zhang, X. L., ... & Li, H. M. (2021). Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population. Journal of Clinical Laboratory Analysis, 35(4), e23732.

Elkoumi, M. A., Abdellatif, S. H., Mohamed, F. Y., Sherif, A. H., Elashkar, S. S., Saleh, R. M., ... & Zeidan, N. M. (2020). Ficolin‐1 gene (FCN1)− 144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under‐five Egyptian children: A multicenter study. Pediatric Pulmonology, 55(5), 1175-1183.

Pieczarka, C., Andrade, F. A., Catarino, S. J., Lidani, K. C. F., Bavia, L., Tizzot, R., ... & de Messias-Reason, I. J. (2020). Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis. Autoimmunity, 53(7), 400-407.

Katayama, M., Ota, K., Nagi-Miura, N., Ohno, N., Yabuta, N., Nojima, H., ... & Hirano, T. (2019). Ficolin-1 is a promising therapeutic target for autoimmune diseases. International immunology, 31(1), 23-32.

Catarino, S. J., Andrade, F. A., Boldt, A. B. W., Guilherme, L., & Messias-Reason, I. J. (2018). Sickening or healing the heart? The association of ficolin-1 and rheumatic fever. Frontiers in immunology, 9, 3009.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rhesus Recombinant FCN1 protein, hFc Tag (CAT#: V2LY-0526-LY9718)

FCN1 Matched Antibody Pair (420) (CAT#: APMAB-420LY)

FCN1 Matched Antibody Pair (421) (CAT#: APMAB-421LY)

Antibody Pairs

FCN1 Matched Antibody Pair (420) (CAT#: APMAB-420LY)

FCN1 Matched Antibody Pair (421) (CAT#: APMAB-421LY)

Related Products

Rabbit Anti-FCN1 Recombinant Antibody (CBXF-1956) (CAT#: CBMAB-F0730-CQ)

Mouse Anti-FCN1 Recombinant Antibody (CBYCL-121) (CAT#: CBMAB-L0022-YC)

Mouse Anti-FCN1 Recombinant Antibody (CBXF-0476) (CAT#: CBMAB-F1433-CQ)

Rhesus Recombinant FCN1 protein, hFc Tag (CAT#: V2LY-0526-LY9718)

Mouse Anti-FCN1 Recombinant Antibody (CBXF-0475) (CAT#: CBMAB-F2292-CQ)

Rabbit Anti-FCN1 Recombinant Antibody (CBXF-1373) (CAT#: CBMAB-F1208-CQ)

FCN1 Matched Antibody Pair (421) (CAT#: APMAB-421LY)

FCN1 Matched Antibody Pair (420) (CAT#: APMAB-420LY)

Mouse Anti-FCN1 Recombinant Antibody (CBXF-0474) (CAT#: CBMAB-F2291-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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