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Mouse Anti-FCN1 Recombinant Antibody (CBYCL-121) (CBMAB-L0022-YC)

Provided herein is a Mouse monoclonal antibody against Human FCN1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all FCN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-121
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombiant full length FCNM protein
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4, with 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ficolin 1
Introduction
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins.However, all these proteins recognize different targets, and are functionally distinct.Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.
Entrez Gene ID
2219
UniProt ID
O00602
Alternative Names
Ficolin 1; Ficolin (Collagen/Fibrinogen Domain-Containing) 1; Ficolin-Alpha; Ficolin-A; M-Ficolin; FCNM; Ficolin (Collagen/Fibrinogen Domain Containing) 1; Collagen/Fibrinogen Domain-Containing Protein 1; Ficolin-1;
Research Area
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097).

Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
Biological Process
Cell surface pattern recognition receptor signaling pathway Source: UniProtKB
Complement activation, lectin pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Positive regulation of interleukin-8 production Source: UniProtKB
Protein localization to cell surface Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB
Cellular Location
Secreted; Cell membrane. Found on the monocyte and granulocyte surface (PubMed:20400674).

Xue, D., Tabib, T., Morse, C., Yang, Y., Domsic, R. T., Khanna, D., & Lafyatis, R. (2022). Expansion of Fcγ Receptor IIIa–Positive Macrophages, Ficolin 1–Positive Monocyte‐Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis. Arthritis & Rheumatology, 74(2), 329-341.

Luo, J., Wang, T., Wang, X., Shi, Y., Zhang, Y., Tian, J., & Gong, Y. (2022). Ficolin-3 may act as a tumour suppressor by recognising O-GlcNAcylation site in hepatocellular carcinoma. Medical Hypotheses, 166, 110899.

Li, Y., You, E. Q., Lin, W. H., Liu, X. N., Shen, D. P., Zhang, X. L., ... & Li, H. M. (2021). Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population. Journal of Clinical Laboratory Analysis, 35(4), e23732.

Elkoumi, M. A., Abdellatif, S. H., Mohamed, F. Y., Sherif, A. H., Elashkar, S. S., Saleh, R. M., ... & Zeidan, N. M. (2020). Ficolin‐1 gene (FCN1)− 144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under‐five Egyptian children: A multicenter study. Pediatric Pulmonology, 55(5), 1175-1183.

Pieczarka, C., Andrade, F. A., Catarino, S. J., Lidani, K. C. F., Bavia, L., Tizzot, R., ... & de Messias-Reason, I. J. (2020). Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis. Autoimmunity, 53(7), 400-407.

Katayama, M., Ota, K., Nagi-Miura, N., Ohno, N., Yabuta, N., Nojima, H., ... & Hirano, T. (2019). Ficolin-1 is a promising therapeutic target for autoimmune diseases. International immunology, 31(1), 23-32.

Catarino, S. J., Andrade, F. A., Boldt, A. B. W., Guilherme, L., & Messias-Reason, I. J. (2018). Sickening or healing the heart? The association of ficolin-1 and rheumatic fever. Frontiers in immunology, 9, 3009.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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