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FGL1

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

Full Name

Fibrinogen Like 1

Function

Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966).

Responsible for LAG3 T-cell inhibitory function (PubMed:30580966).

Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966).

Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).

Biological Process

Adaptive immune response Source: UniProtKB-KW
Hepatocyte proliferation Source: UniProtKB
Negative regulation of T cell activation Source: UniProtKB
Regulation of immune response Source: UniProtKB

Cellular Location

Secreted. Secreted in the blood plasma.

Anti-FGL1 antibodies

Mouse Anti-FGL1 Recombinant Antibody (2A4) (CBMAB-A2959-LY)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2A4

Application*: WB, E

Mouse Anti-FGL1 Recombinant Antibody (CBXF-1660) (CBMAB-F4084-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1660

Application*: WB

Mouse Anti-FGL1 (AA 19-312) Recombinant Antibody (CBXF-3000) (CBMAB-F3706-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3000

Application*: E, WB

Mouse Anti-FGL1 Recombinant Antibody (CBXF-2999) (CBMAB-F3705-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXF-2999

Application*: E, IP, WB

Mouse Anti-FGL1 Recombinant Antibody (CBXF-1745) (CBMAB-F3280-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXF-1745

Application*: WB, IP, IF, E

Mouse Anti-FGL1 Recombinant Antibody (CBXF-0645) (CBMAB-F2675-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-0645

Application*: WB, IC, P, E

Mouse Anti-FGL1 Recombinant Antibody (CBXF-0644) (CBMAB-F1448-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBXF-0644

Application*: WB, IC, P, C, E

Mouse Anti-FGL1 Recombinant Antibody (CBXF-2171) (CBMAB-F1366-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-2171

Application*: WB

Rabbit Anti-FGL1 Recombinant Antibody (CBXF-1271) (CBMAB-F0884-CQ)

SDS

Target: FGL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1271

Application*: WB, IP

Rabbit Anti-FGL1 Recombinant Antibody (CBXF-1270) (CBMAB-F0883-CQ)

SDS

Target: FGL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1270

Application*: WB

Mouse Anti-FGL1 Recombinant Antibody (CBXF-0642) (CBMAB-F0882-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXF-0642

Application*: WB

Mouse Anti-FGL1 (AA 23-312) Recombinant Antibody (CBXF-0643) (CBMAB-F0295-CQ)

SDS

Target: FGL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-0643

Application*: E, IC, WB

FGL1 Matched Antibody Pair (441) (APMAB-441LY)

SDS

Target: FGL1

Specificity: Human

FGL1 Matched Antibody Pair (440) (APMAB-440LY)

SDS

Target: FGL1

Specificity: Human

FGL1 Matched Antibody Pair (439) (APMAB-439LY)

SDS

Target: FGL1

Specificity: Human

FGL1 Matched Antibody Pair (438) (APMAB-438LY)

SDS

Target: FGL1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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