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Human Recombinant FGL1 protein, hFc Tag (V2LY-0526-LY4133)

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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
hFc Tag
Protein Construction
This product is Human Recombinant FGL1 protein, hFc Tag consist of Amino Acid: 1-312 and predicts a molecular mass of 60.7 kDa.
Molecule Mass
60.7 kDa
Sequence
Amino Acid: 1-312
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Fibrinogen Like 1
Function
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966).

Responsible for LAG3 T-cell inhibitory function (PubMed:30580966).

Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966).

Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Hepatocyte proliferation Source: UniProtKB
Negative regulation of T cell activation Source: UniProtKB
Regulation of immune response Source: UniProtKB
Cellular Location
Secreted. Secreted in the blood plasma.

Liu, X. H., Qi, L. W., Alolga, R. N., & Liu, Q. (2022). Implication of the hepatokine, fibrinogen-like protein 1 in liver diseases, metabolic disorders and cancer: The need to harness its full potential. International Journal of Biological Sciences, 18(1), 292.

Piórkowska, K., Żukowski, K., Ropka-Molik, K., & Tyra, M. (2022). Variations in Fibrinogen-like 1 (FGL1) Gene Locus as a Genetic Marker Related to Fat Deposition Based on Pig Model and Liver RNA-Seq Data. Genes, 13(8), 1419.

Hua, N., Chen, A., Yang, C., Dong, H., He, X., Ru, G., ... & Wang, S. (2022). The correlation of fibrinogen-like protein-1 expression with the progression and prognosis of hepatocellular carcinoma. Molecular Biology Reports, 49(8), 7911-7919.

Qian, W., Zhao, M., Wang, R., & Li, H. (2021). Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target. Journal of Hematology & Oncology, 14(1), 1-17.

Son, Y., Shin, N. R., Kim, S. H., Park, S. C., & Lee, H. J. (2021). Fibrinogen-like protein 1 modulates sorafenib resistance in human hepatocellular carcinoma cells. International Journal of Molecular Sciences, 22(10), 5330.

Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., ... & Li, H. Y. (2020). Targeting fibrinogen‐like protein 1 is a novel therapeutic strategy to combat obesity. The FASEB Journal, 34(2), 2958-2967.

Kang, L., Li, H. Y., Ou, H. Y., Wu, P., Wang, S. H., Chang, C. J., ... & Wu, H. T. (2020). Role of placental fibrinogen-like protein 1 in gestational diabetes. Translational Research, 218, 73-80.

Wang, J., Sanmamed, M. F., Datar, I., Su, T. T., Ji, L., Sun, J., ... & Chen, L. (2019). Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell, 176(1-2), 334-347.

Zhang, Y., Qiao, H. X., Zhou, Y. T., Hong, L., & Chen, J. H. (2018). Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis. Molecular medicine reports, 18(2), 1465-1472.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant FGL1 protein, hFc Tag (CAT#: V2LY-0526-LY1517)

Cynomolgus Recombinant FGL1 protein, His Tag (CAT#: V2LY-0526-LY1518)

Human Recombinant FGL1 protein, His & AVI Tag (CAT#: V2LY-0526-LY4134)

Human Recombinant FGL1 protein, His Tag (CAT#: V2LY-0526-LY4135)

Human Recombinant FGL1 protein, Fc Tag (CAT#: V2LY-0526-LY4136)

Mouse Recombinant FGL1 protein, hFc Tag (CAT#: V2LY-0526-LY8324)

Mouse Recombinant FGL1 protein, His Tag (CAT#: V2LY-0526-LY8325)

Rat Recombinant FGL1 protein, His Tag (CAT#: V2LY-0526-LY9381)

Human FGL1 ELISA Kit (CAT#: V2LY-0626-LY3737)

FGL1 Matched Antibody Pair (438) (CAT#: APMAB-438LY)

Antibody Pairs

FGL1 Matched Antibody Pair (438) (CAT#: APMAB-438LY)

FGL1 Matched Antibody Pair (439) (CAT#: APMAB-439LY)

FGL1 Matched Antibody Pair (440) (CAT#: APMAB-440LY)

FGL1 Matched Antibody Pair (441) (CAT#: APMAB-441LY)

Related Products

Rabbit Anti-FGL1 Recombinant Antibody (CBXF-1270) (CAT#: V2LY-0925-LY1820)

Rat Anti-FGL1 Recombinant Antibody (CBXF-0643) (CAT#: V2LY-0925-LY1818)

Human Recombinant FGL1 protein, His Tag (CAT#: V2LY-0526-LY4135)

Mouse Anti-FGL1 Recombinant Antibody (CBXF-1745) (CAT#: V2LY-0925-LY1825)

Human Recombinant FGL1 protein, His & AVI Tag (CAT#: V2LY-0526-LY4134)

FGL1 Matched Antibody Pair (439) (CAT#: APMAB-439LY)

FGL1 Matched Antibody Pair (441) (CAT#: APMAB-441LY)

Mouse Recombinant FGL1 protein, hFc Tag (CAT#: V2LY-0526-LY8324)

Rat Recombinant FGL1 protein, His Tag (CAT#: V2LY-0526-LY9381)

Cynomolgus Recombinant FGL1 protein, hFc Tag (CAT#: V2LY-0526-LY1517)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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