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Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441)


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Tested Data
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in ELISA
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in ELISA
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in WB
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in WB
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in WB
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in WB
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in FC
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in FC
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in FC
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in FC
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in IHC
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in IHC
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in IHC
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in IHC
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in IF
Mouse Anti-FGL1 Recombinant Antibody (CBT2865) (V2LY-0625-LY1441) in IF

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2865
Antibody Isotype
IgG2a
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human FGL1 (AA: 23-312) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
2267
UniProt ID
Q08830
Function
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966).

Responsible for LAG3 T-cell inhibitory function (PubMed:30580966).

Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966).

Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Hepatocyte proliferation Source: UniProtKB
Negative regulation of T cell activation Source: UniProtKB
Regulation of immune response Source: UniProtKB
Cellular Location
Secreted. Secreted in the blood plasma.
More Infomation

Liu, X. H., Qi, L. W., Alolga, R. N., & Liu, Q. (2022). Implication of the hepatokine, fibrinogen-like protein 1 in liver diseases, metabolic disorders and cancer: The need to harness its full potential. International Journal of Biological Sciences, 18(1), 292.

Piórkowska, K., Żukowski, K., Ropka-Molik, K., & Tyra, M. (2022). Variations in Fibrinogen-like 1 (FGL1) Gene Locus as a Genetic Marker Related to Fat Deposition Based on Pig Model and Liver RNA-Seq Data. Genes, 13(8), 1419.

Hua, N., Chen, A., Yang, C., Dong, H., He, X., Ru, G., ... & Wang, S. (2022). The correlation of fibrinogen-like protein-1 expression with the progression and prognosis of hepatocellular carcinoma. Molecular Biology Reports, 49(8), 7911-7919.

Qian, W., Zhao, M., Wang, R., & Li, H. (2021). Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target. Journal of Hematology & Oncology, 14(1), 1-17.

Son, Y., Shin, N. R., Kim, S. H., Park, S. C., & Lee, H. J. (2021). Fibrinogen-like protein 1 modulates sorafenib resistance in human hepatocellular carcinoma cells. International Journal of Molecular Sciences, 22(10), 5330.

Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., ... & Li, H. Y. (2020). Targeting fibrinogen‐like protein 1 is a novel therapeutic strategy to combat obesity. The FASEB Journal, 34(2), 2958-2967.

Kang, L., Li, H. Y., Ou, H. Y., Wu, P., Wang, S. H., Chang, C. J., ... & Wu, H. T. (2020). Role of placental fibrinogen-like protein 1 in gestational diabetes. Translational Research, 218, 73-80.

Wang, J., Sanmamed, M. F., Datar, I., Su, T. T., Ji, L., Sun, J., ... & Chen, L. (2019). Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell, 176(1-2), 334-347.

Zhang, Y., Qiao, H. X., Zhou, Y. T., Hong, L., & Chen, J. H. (2018). Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis. Molecular medicine reports, 18(2), 1465-1472.

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For research use only. Not intended for any clinical use.

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