FLT3LG

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

Fms Related Tyrosine Kinase 3 Ligand

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Embryonic hemopoiesis Source: DFLAT
Positive regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc

Isoform 1: Cell membrane
Isoform 2: Secreted

Extracellular: 27-184
Helical: 185-205
Cytoplasmic: 206-235