FLT3LG
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
Full Name
Fms Related Tyrosine Kinase 3 Ligand
Function
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
Biological Process
Embryonic hemopoiesis Source: DFLAT
Positive regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc
Positive regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 2: Secreted
Topology
Extracellular: 27-184
Helical: 185-205
Cytoplasmic: 206-235
Helical: 185-205
Cytoplasmic: 206-235
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Anti-FLT3LG antibodies
+ Filters

Target: FLT3LG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1215
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Target: FLT3LG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP773
Application*: ICC, IHC, IP, WB
Target: FLT3LG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3089
Application*: E, WB
Target: FLT3LG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBXF-1041
Application*: WB, P, F, IF
Target: FLT3LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D10
Application*: IF, WB
Target: FLT3LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2246
Application*: E, N, WB
Target: FLT3LG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0759
Application*: E, IC, WB
Target: FLT3LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3325
Application*: WB, N
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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