Mouse Anti-FLT3LG Recombinant Antibody (CAP773) (CBMAB-AP2315LY)

Name: Mouse Anti-FLT3LG Recombinant Antibody (CAP773)
SKU: CBMAB-AP2315LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CAP773

Application

ICC, IHC, IP, WB

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Fms Related Tyrosine Kinase 3 Ligand

Introduction

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

Entrez Gene ID

2323

UniProt ID

P49771

Alternative Names

Fms Related Tyrosine Kinase 3 Ligand; Fms-Related Tyrosine Kinase 3 Ligand; Flt3 Ligand; FLT3L; SL Cytokine; FLG3L; FL;

Function

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Biological Process

Embryonic hemopoiesis Source: DFLAT
Positive regulation of cell population proliferation Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted

Topology

Extracellular: 27-184
Helical: 185-205
Cytoplasmic: 206-235

Chen, L., Huang, Y., Dong, B., Gu, Y., Li, Y., Cang, W., ... & Xiang, Y. (2022). Low Level FLT3LG is a Novel Poor Prognostic Biomarker for Cervical Cancer with Immune Infiltration. Journal of Inflammation Research, 5889-5904.

Chen, H., Wu, M., Xia, H., Du, S., Zhou, G., Long, G., ... & Yang, D. (2022). FLT3LG and IFITM3P6 consolidate T cell activity in the bone marrow microenvironment and are prognostic factors in acute myelocytic leukemia. Frontiers in Immunology, 13.

Maiorova, V., Mollaev, M. D., Vikhreva, P., Kulakovskaya, E., Pershin, D., Chudakov, D. M., ... & Larin, S. (2021). Natural Flt3Lg-based chimeric antigen receptor (Flt3-CAR) T cells successfully target Flt3 on AML cell lines. Vaccines, 9(11), 1238.

Pol, J. G., Le Naour, J., & Kroemer, G. (2020). FLT3LG-a biomarker reflecting clinical responses to the immunogenic cell death inducer oxaliplatin. Oncoimmunology, 9(1), 1755214.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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