FNTA

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Related pseudogenes have been identified on chromosomes 11 and 13.

Full Name

Farnesyltransferase, CAAX Box, Alpha

Function

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Biological Process

Neurotransmitter receptor metabolic process Source: Ensembl
Positive regulation of deacetylase activity Source: BHF-UCL
Positive regulation of tubulin deacetylation Source: BHF-UCL
Protein farnesylation Source: UniProtKB
Protein geranylgeranylation Source: UniProtKB
Skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: ProtInc

Cellular Location

Microtubule associated complex; Cytosol; Plasma membrane; CAAX-protein geranylgeranyltransferase complex; Cytoplasm; Protein farnesyltransferase complex

PTM

Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).