Mouse Anti-FNTA Recombinant Antibody (CBXF-3111) (CBMAB-F3807-CQ)

Name: Mouse Anti-FNTA Recombinant Antibody (CBXF-3111)
SKU: CBMAB-F3807-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3111

Application

Immunogen

Full length GST-farnesyltransferase, alpha subunit protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Farnesyltransferase, CAAX Box, Alpha

Introduction

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13.

Entrez Gene ID

2339

UniProt ID

P49354

Alternative Names

Farnesyltransferase, CAAX Box, Alpha; Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha; Protein Prenyltransferase Alpha Subunit Repeat Containing 2; Ras Proteins Prenyltransferase Subunit Alpha; GGTase-I-Alpha; FTase-Alpha; Type I Protein Geranyl-Geranyltransferase Alpha Subunit; Type I Protein Geranyl-Geranyltransferase Subunit Alpha;

Function

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Biological Process

Neurotransmitter receptor metabolic process Source: Ensembl
Positive regulation of deacetylase activity Source: BHF-UCL
Positive regulation of tubulin deacetylation Source: BHF-UCL
Protein farnesylation Source: UniProtKB
Protein geranylgeranylation Source: UniProtKB
Skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: ProtInc

Cellular Location

Microtubule associated complex; Cytosol; Plasma membrane; CAAX-protein geranylgeranyltransferase complex; Cytoplasm; Protein farnesyltransferase complex

PTM

Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).

Chen, J., Sun, Y., Ou, Z., Yeh, S., Huang, C. P., You, B., ... & Chang, C. (2020). Androgen receptor‐regulated circ FNTA activates KRAS signaling to promote bladder cancer invasion. EMBO reports, 21(4), e48467.

Tian, J., Fan, J., Xu, J., Ren, T., Guo, H., & Zhou, L. (2020). circ‑FNTA accelerates proliferation and invasion of bladder cancer. Oncology letters, 19(1), 1017-1023.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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