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Rabbit Anti-FNTA Recombinant Antibody (CBXF-1203) (CBMAB-F0934-CQ)

This product is a rabbit antibody that recognizes FNTA. The antibody CBXF-1203 can be used for immunoassay techniques such as: WB, IHC-P, FC.
See all FNTA antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1203
Antibody Isotype
IgG
Application
WB, IHC-P, FC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Farnesyltransferase, CAAX Box, Alpha
Introduction
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13.
Entrez Gene ID
Human2339
Mouse14272
Rat25318
UniProt ID
HumanP49354
MouseQ61239
RatQ04631
Alternative Names
Farnesyltransferase, CAAX Box, Alpha; Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha; Protein Prenyltransferase Alpha Subunit Repeat Containing 2; Ras Proteins Prenyltransferase Subunit Alpha; GGTase-I-Alpha; FTase-Alpha; Type I Protein Geranyl-Geranyltransferase Alpha Subunit; Type I Protein Geranyl-Geranyltransferase Subunit Alpha;
Function
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
Biological Process
Neurotransmitter receptor metabolic process Source: Ensembl
Positive regulation of deacetylase activity Source: BHF-UCL
Positive regulation of tubulin deacetylation Source: BHF-UCL
Protein farnesylation Source: UniProtKB
Protein geranylgeranylation Source: UniProtKB
Skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: ProtInc
Cellular Location
Microtubule associated complex; Cytosol; Plasma membrane; CAAX-protein geranylgeranyltransferase complex; Cytoplasm; Protein farnesyltransferase complex
PTM
Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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