FYB1

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene.
Full Name
FYN binding protein 1
Function
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity).

May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616).

Modulates the expression of IL2 (By similarity).

Involved in platelet activation (By similarity).

Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195).

May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).
Biological Process
Immune response Source: ProtInc
Integrin-mediated signaling pathway Source: GO_Central
Protein localization to plasma membrane Source: GO_Central
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Nucleus; Cytoplasm; Cell junction. Colocalizes with TMEM47 at cell-cell contacts in podocytes.
Involvement in disease
Thrombocytopenia 3 (THC3):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC3 is an autosomal recessive form characterized by onset in infancy.
PTM
T-cell receptor ligation leads to increased tyrosine phosphorylation.
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Anti-FYB1 antibodies

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Mouse Anti-FYB1 Recombinant Antibody (EG1249) (CBMAB-EN1510-LY)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: EG1249
Application*: WB, ICC
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CAP803) (CBMAB-AP2423LY)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP803
Application*: WB
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CAP802) (CBMAB-AP2422LY)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CAP802
Application*: ELISA, ICC, WB
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CAP801) (CBMAB-AP2421LY)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CAP801
Application*: ELISA, ICC, WB
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CB424A) (CBMAB-CA424LY)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CB424A
Application*: ELISA, WB, ICC
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CBXF-1815) (CBMAB-F3350-CQ)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1815
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CBXF-2690) (CBMAB-F3095-CQ)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXF-2690
Application*: WB
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CBXF-0974) (CBMAB-F2687-CQ)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXF-0974
Application*: E, WB, IC
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CBXF-0975) (CBMAB-F1752-CQ)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0975
Application*: ID, WB
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CBXF-1982) (CBMAB-F1523-CQ)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1982
Application*: WB, IF
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CBXF-2421) (CBMAB-F1163-CQ)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2421
Application*: WB
Datasheet SDS

Rabbit Anti-FYB1 Recombinant Antibody (CBXF-1166) (CBMAB-F1004-CQ)

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Target: FYB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-1166
Application*: WB, P, IC
Datasheet SDS

Rabbit Anti-FYB1 Recombinant Antibody (CBXF-1052) (CBMAB-F0558-CQ)

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Target: FYB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1052
Application*: WB, P, IC, F, IF
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CBXF-2689) (CBMAB-F0159-CQ)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2689
Application*: IS
Datasheet SDS

Mouse Anti-FYB1 Recombinant Antibody (CBT573) (V2LY-0625-LY3415)

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Target: FYB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBT573
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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