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Mouse Anti-FYB1 Recombinant Antibody (CAP802) (CBMAB-AP2422LY)


See all FYB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CAP802
Antibody Isotype
IgG
Application
ELISA, ICC, WB

Basic Information

Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FYN binding protein 1
Introduction
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Entrez Gene ID
Human2533
Rat499537
UniProt ID
HumanO15117
RatD3ZIE4
Alternative Names
FYN Binding Protein 1; Adhesion And Degranulation Promoting Adaptor Protein; SLP-76-Associated Phosphoprotein; FYN-T-Binding Protein; FYB-120/130; P120/P130; SLAP-130; SLAP130; ADAP;
Function
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity).

May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616).

Modulates the expression of IL2 (By similarity).

Involved in platelet activation (By similarity).

Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195).

May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).
Biological Process
Immune response Source: ProtInc
Integrin-mediated signaling pathway Source: GO_Central
Protein localization to plasma membrane Source: GO_Central
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Nucleus; Cytoplasm; Cell junction. Colocalizes with TMEM47 at cell-cell contacts in podocytes.
Involvement in disease
Thrombocytopenia 3 (THC3):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC3 is an autosomal recessive form characterized by onset in infancy.
PTM
T-cell receptor ligation leads to increased tyrosine phosphorylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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