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GCKR

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
Full Name
glucokinase regulator
Function
Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961).

Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334).

The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961).
Biological Process
Carbohydrate derivative metabolic process Source: InterPro
Carbohydrate metabolic process Source: UniProtKB-KW
Glucose homeostasis Source: GO_Central
Negative regulation of glucokinase activity Source: UniProtKB
Protein import into nucleus Source: BHF-UCL
Response to fructose Source: BHF-UCL
Triglyceride homeostasis Source: BHF-UCL
Urate metabolic process Source: BHF-UCL
Cellular Location
Cytoplasm; Mitochondrion; Nucleus. Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
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Anti-GCKR antibodies

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Mouse Anti-GCKR Recombinant Antibody (CAP842) (CBMAB-AP2537LY)

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Target: GCKR
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP842
Application*: ICC, IHC, IP, WB
Datasheet SDS

Rabbit Anti-GCKR Recombinant Antibody (D1W9P) (CBMAB-G2623-LY)

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Target: GCKR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D1W9P
Application*: WB
Datasheet SDS

Mouse Anti-GCKR Recombinant Antibody (CBLG1-1246) (CBMAB-G3642-LY)

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Target: GCKR
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-1246
Application*: WB
Datasheet SDS

Mouse Anti-GCKR Recombinant Antibody (CBLG1-803) (CBMAB-G2627-LY)

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Target: GCKR
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-803
Application*: E
Datasheet SDS

Mouse Anti-GCKR Recombinant Antibody (CBLG1-802) (CBMAB-G2626-LY)

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Target: GCKR
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-802
Application*: E, WB
Datasheet SDS

Mouse Anti-GCKR Recombinant Antibody (CBLG1-2678) (CBMAB-G2624-LY)

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Target: GCKR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2678
Application*: WB
Datasheet SDS

Mouse Anti-GCKR Recombinant Antibody (4) (CBMAB-G2621-LY)

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Target: GCKR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: 4
Application*: WB
Datasheet SDS

Mouse Anti-GCKR Recombinant Antibody (CBLG1-057) (CBMAB-G0297-LY)

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Target: GCKR
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-057
Application*: E, IC, WB
Datasheet SDS

Rabbit Anti-GCKR Recombinant Antibody (EG1300) (CBMAB-EN1572-LY)

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Target: GCKR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1300
Application*: WB: 1:500~1:1000 ELISA: 1:5000
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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