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Rabbit Anti-GCKR Recombinant Antibody (EG1300) (CBMAB-EN1572-LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
EG1300
Application
WB: 1:500~1:1000 ELISA: 1:5000
Immunogen
The antibody was produced against synthesized peptide derived from internal of human Glucokinase Regulator.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
glucokinase regulator
Introduction
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
Entrez Gene ID
Human2646
Mouse231103
Rat25658
UniProt ID
HumanQ14397
MouseQ91X44
RatQ07071
Alternative Names
GKRP; FGQTL5
Function
Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961).

Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334).

The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961).
Biological Process
Carbohydrate derivative metabolic process Source: InterPro
Carbohydrate metabolic process Source: UniProtKB-KW
Glucose homeostasis Source: GO_Central
Negative regulation of glucokinase activity Source: UniProtKB
Protein import into nucleus Source: BHF-UCL
Response to fructose Source: BHF-UCL
Triglyceride homeostasis Source: BHF-UCL
Urate metabolic process Source: BHF-UCL
Cellular Location
Cytoplasm; Mitochondrion; Nucleus. Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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