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Mouse Anti-GCKR Recombinant Antibody (CAP842) (CBMAB-AP2537LY)


See all GCKR antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CAP842
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Val90~Ala286
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glucokinase regulator
Introduction
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]
Entrez Gene ID
25658
UniProt ID
Q07071
Alternative Names
Glucokinase Regulator; Hexokinase 4 Regulator; GKRP; Glucokinase (Hexokinase 4) Regulatory Protein; Glucokinase (Hexokinase 4) Regulator; Glucokinase Regulatory Protein; FGQTL5;
Function
Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961).

Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334).

The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961).
Biological Process
Carbohydrate derivative metabolic process Source: InterPro
Carbohydrate metabolic process Source: UniProtKB-KW
Glucose homeostasis Source: GO_Central
Negative regulation of glucokinase activity Source: UniProtKB
Protein import into nucleus Source: BHF-UCL
Response to fructose Source: BHF-UCL
Triglyceride homeostasis Source: BHF-UCL
Urate metabolic process Source: BHF-UCL
Cellular Location
Cytoplasm; Mitochondrion; Nucleus. Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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