GPR107

Full Name

G Protein-Coupled Receptor 107

Function

Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024).

Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).

(Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.

Biological Process

Clathrin-dependent endocytosis Source: GO_Central

Cellular Location

Trans-Golgi network membrane; Cell membrane

Topology

Extracellular: 40-263
Helical: 264-284
Cytoplasmic: 285-293
Helical: 294-314
Extracellular: 315-337
Helical: 338-358
Cytoplasmic: 359-368
Helical: 369-389
Extracellular: 390-402
Helical: 403-423
Cytoplasmic: 424-498
Helical: 499-519
Extracellular: 520-524
Helical: 525-544
Cytoplasmic: 545-600

PTM

Cleaved by FURIN to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.